Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (4): 499-503.doi: 10.3969/j.issn.2095-4344.2359

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Comparison of different bioactive scaffolds in the treatment of regenerative pulp of young permanent teeth

Li Wenjing, Li Haobo, Liu Congna, Cheng Dongmei, Chen Huizhen, Zhang Zhiyong   

  1. Department of Oral Medicine, Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
  • Received:2019-11-16 Revised:2019-11-20 Accepted:2020-02-14 Online:2021-02-08 Published:2020-11-21
  • Contact: Zhang Zhiyong, Chief physician, Department of Oral Medicine, Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
  • About author:Li Wenjing, Master, Associate chief physician, Department of Oral Medicine, Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
  • Supported by:
    the Science and Technology Plan Project of Hebei Province, No. 17277795D

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Abstract: BACKGROUND: Regenerative endodontic therapy has the advantages of good biocompatibility, complete root development and high pulp vitality preservation rate. During vascular regeneration, scaffold is needed to maintain the survival of stem cells and vascular regeneration.   
OBJECTIVE: To analyze the effect of different bioactive scaffolds on regenerative pulp of young permanent teeth.
METHODS: Totally 160 patients (168 teeth) with acute pulpitis at the age of 8 to 16 years, who were treated in the Second Hospital of Hebei Medical University from June 2016 to June 2018, were enrolled in this study. The patients were divided into traumatic group (n=92) and dental caries group (n=76) according to a cause of a disease. Each group was subdivided into mineral trioxide aggregate (MTA), iRoot BP Plus, autologous platelet-rich fibrin (PRF)+MTA and acellular dermal matrix (ADM)+MTA subgroups. The corresponding stents were used to treat regenerative pulp. At 1, 3, 6, 12 and 24 months, the tooth color, pulp vitality, and eruption height were recorded. Root canal length, root canal wall thickness, periapical shadow and apical foramen closure were compared using X-ray photography; and the success rate was calculated. This study was approved by the Ethics Committee of Second Hospital of Hebei Medical University. 
RESULTS AND CONCLUSION:  (1) At the final follow-up in the traumatic group, tooth color, pulp vitality and eruption height were not significantly different among the four scaffold subgroups (P > 0.05). Root canal length, root canal wall thickness, periapical shadow and apical foramen occlusion were significantly different among the four scaffold subgroups (P < 0.05). Among them, the effect was best in the PRF+MTA subgroup. (2) At the final follow-up in the dental caries group, tooth color, pulp vitality and eruption height were not significantly different among the four scaffold subgroups (P > 0.05). Root canal length, root canal wall thickness, periapical shadow and apical foramen occlusion were significantly different among the four scaffold subgroups (P < 0.05). Among them, the effect was best in the PRF+MTA subgroup. (3) No matter traumatic group or dental caries group, the success rate was significantly different among the four scaffold subgroups (P < 0.05); and the success rate was highest in the PRF+MTA subgroup. (4) Results verified that PRF combined with MTA has excellent biological induction in the treatment of young permanent teeth with regenerative pulp. Compared with other scaffolds, it can better preserve pulp vitality, induce the formation of young permanent teeth roots and improve the success rate of treatment.

Key words: materials, scaffolds, bioactive scaffolds, pulp, pulpitis, permanent teeth, pulp vitality, biological induction

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