Clinical efficacy of calcium sulphate/demineralized bone matrix versus bone allograft in anterior cervical discectomy and fusion

doi:10.3969/j.issn.2095-4344.2323

Abstract

Abstract:

BACKGROUND: Different bone graft substitutes are widely used in clinical bone repair and tissue reconstruction. However, it remains unclear what bone graft substitute can acquire good bone fusion.

OBJECTIVE: To investigate the clinical efficacy of different bone grafts filled in Zero-P cage for single-segment anterior cervical discectomy and fusion to treat cervical radiculopathy.

METHODS: Seventy-seven patients with cervical radiculopathy who received treatment in the Second Hospital of Shanxi Medical University between January 2017 and January 2019 were included in this study. All included patients underwent single-segment anterior cervical discectomy and fusion and were divided into three groups according to bone graft materials: calcium sulphate/demineralized bone matrix group (n=27), allogeneic bone group (n=24), and autologous bone group (n=26). After surgery, 1-year follow up was performed. The Japanese Orthopedic Association (JOA) score, Visual Analog Scale (VAS) score, and Neck Disability Index (NDI) were evaluated. Changes in bone fusion, cervical curvature, and the height of intervertebral space were observed by imaging examination. This study was approved by the Hospital Ethics Committee, Second Hospital of Shanxi Medical University, China.

RESULTS AND CONCLUSION: (1) Compared with before surgery, JOA score was significantly increased, VAS score, and NDI were significantly decreased in each group at 1 year after surgery (P < 0.05). There were no significant differences in JOA score, VAS score, and NDI among three groups at 1 year after surgery (P > 0.05). (2) Compared with before surgery, cervical curvature and the height of intervertebral space were significantly increased in each group at 1 year after surgery (P < 0.05). There were no significant differences in cervical curvature and the height of intervertebral space between groups (P > 0.05). (3) At 6 months after surgery, bone fusion was observed in each group, and the degree of bone fusion in the calcium sulphate/demineralized bone matrix group was similar to that in the autologous bone group (P > 0.05), and the degree of bone fusion in the allogeneic bone group was lower than that in the autologous bone group (P < 0.05). (4) These results suggest that calcium sulphate/demineralized bone matrix for anterior cervical discectomy and fusion can acquire good bone fusion, and the clinical efficacy of calcium sulphate/demineralized bone matrix is similar to that of autologous bone and superior to that of allogenic bone.

Key words: cervical spondylosis">, , Zero-P case">, , calcium sulphate/demineralized bone matrix">, , allogeneic bone">, , autologous bone">, , anterior cervical discectomy and fusion">, , bone fusion

CLC Number:

Li Yongtao, Song Wenhui, Liu Changwen, Liang Kaiheng, Zhang Kaixi, Liu Changfeng. Clinical efficacy of calcium sulphate/demineralized bone matrix versus bone allograft in anterior cervical discectomy and fusion[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(34): 5478-5485.

Figures/Tables 17

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