Chinese Journal of Tissue Engineering Research ›› 2020, Vol. 24 ›› Issue (34): 5552-5558.doi: 10.3969/j.issn.2095-4344.2318

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Preparation of injectable tantalum oxide-loaded brushite bone cement and investigation on its radiocapacity performance

Xing Yuying1, He Yuying1, Jiang Ningning1, Zhu Ruijie1, He Ran1, Qi Yangkun1, Wang Kejing2, Li Guangda1   

  1. 1School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, Henan Province, China; 2School of Basic Medical Science, Xinxiang Medical University, Xinxiang 453000, Henan Province, China

  • Received:2019-09-26 Revised:2019-09-28 Accepted:2020-02-26 Online:2020-11-08 Published:2020-09-11
  • Contact: Li Guangda, PhD, Associate professor, Master’s supervisor, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, Henan Province, China
  • About author:Xing Yuying, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, Henan Province, China He Yuying, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, Henan Province, China
  • Supported by:
    the National Natural Science Foundation, Nos. 81402225, U1304805; Key Scientific and Technological Project of Henan Province, No. 182102311114; Young Backbone Teachers Project in Henan Higher Education Institution, No. 2018GGJS050; Student Research Training Program from Hennan Province, No. 201810464022.  

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Abstract:

BACKGROUND: Brushite bone cement has similar chemical composition to human bone tissue, and thus it is difficult to differentiate the cement and the bone on X-ray images due to their similar radiocapicity, limiting the clinical application of the material. However, as far as we know, few researches focus on the improvement of the radiocapacity of brushite bone cement.

OBJECTIVE: To prepare injectable tantalum oxide-loaded brushite bone cement and investigate the effects of tantalum on injectability, microstructure, radiopacity, compressive strength, and cyto-biocompatibility of tantalum-loaded brushite bone cement.

METHODS: The powder of brushite bone cement was prepared by mixing β-calcium phosphate and dicalcium phosphate at the molar ratio of 1:1. Then 0 wt%, 1 wt%, 3 wt%, and 5 wt% tantalum oxide was added to the powder of brushite bone cement. Solid phase bone cement was mixed with chitosan-containing citric acid solidified solution to prepare injectable brushite bone cement loaded with different amounts of tantalum oxide. The solidification time, injectability, micromorphology, crystal phase composition, chemical group, radiopacity, compressive strength, biodegradability and cytocompatibility of the tantalum-loaded brushite bone cement were tested.

RESULTS AND CONCLUSION: (1) With the increase of the proportion of tantalum oxide, the solidification time of bone cement gradually prolonged and the bone cement maintained good anti-washout ability and injectability. (2) The addition of tantalum oxide did not greatly change the crystal structure and group composition of brushite bone cement, but obviously changed the surface appearance of the material. (3) The addition of tantalum oxide increased the compressive strength of brushite bone cement, but decreased its compressive strength. (4) With the increase of the proportion of tantalum oxide added, the radiopacity of brushite bone cement was gradually enhanced. (5) The injectable brushite bone cement loaded with different amounts of tantalum oxide had no cytotoxicity, and MG63 cells normally adhered to and proliferated on its surface. (6) These findings suggest that injectable tantalum oxide-loaded brushite bone cement has good injectability, radiopacity, compressive strength, biodegradability, and cytocompatibility.   

Key words: brushite bone cement">,  , radiopacity">,  , tantalum oxide">,  , cytocompatibility">,  , injectability">,  , compressive strength">,  , phase composition">,  , biodegradability

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