Preparation and mechanical properties
of zirconia-based nano-hydroxyapatite functionally graded material

doi:10.3969/j.issn.2095-4344.2234

Abstract

Abstract:

BACKGROUND: Studies have shown that the nano-hydroxyapatite coating on the surface of zirconia has not only high strength and toughness, but also good biocompatibility. It is an ideal substitute for hard tissue. However, the coating is easy to fall off from the surface of zirconia, which is a fatal defect.

OBJECTIVE: To prepare functionally graded bioceramics with pure zirconia as matrix, gradient layer in the middle and nano-hydroxyapatite on the surface by gradient composite technology and to screen the optimal mechanical properties and sintering temperature.

METHODS: Using zirconia and nano hydroxyapatite powder as raw materials, ceramic specimens were prepared by the lamination method in powder metallurgy. According to the thickness of zirconia layer, three groups A (40 mm), B (30 mm) and C (20 mm) were designated. Each group was sub-divided into three subgroups 1 (3 layers), 2 (5 layers) and 3 (7 layers). Thus, there were 162 ceramic specimens in nine subgroups. The ceramic specimens were sintered at different temperatures (1 300, 1 350, 1 400, 1 450, 1500, and 1 550 °C) and then processed into rectangular specimens for mechanical property testing.

RESULTS AND CONCLUSION: The zirconia-based nano-hydroxyapatite functionally graded material can be formed by 10 MPa single side vertical pressure. With the increases in the number of gradient layers and sintering temperature, the mechanical properties of the functionally graded bioceremics in each group were enhanced. The functionally graded bioceramics had the optimal mechanical properties when sintering temperature was 1 550 °C, the number of gradient layers was 7, and substrate thickness was 40 mm. The optimal mechanical property of the functionally graded bioceramics produced at above parameter was significantly superior to that produced at other eight sets of parameters (P < 0.05). According to the optimal gradient design, the zirconia-based nano-hydroxyapatite functionally graded ceramic specimens prepared by high temperature sintering technique have stronger mechanical properties.

Key words: zirconia, nano-hydroxyapatite, functionally graded material, hard tissue substitute, sintering, ceramics, bending strength, shearing strength, biocompatibility, bioactivity

CLC Number:

Niu Yueyue, Wang Chunyan, Shu Jingyuan, Cui Yingying, Liu Zhen, Gao Yan, Wang Qian, Wang Qingshan. Preparation and mechanical properties of zirconia-based nano-hydroxyapatite functionally graded material[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(10): 1528-1533.

Figures/Tables 3

References

[1] 许力强,宋文植,孙宏晨.放电等离子烧结法制备牙科纳米氧化锆复相陶瓷力学性能研究[J].广东牙病防治,2014,22(8):440-412.
[2] 赵露,吴音,郭兴国,等.浸渗掺杂技术制备彩色氧化锆陶瓷[J].稀有金属材料与工程,2018,47(S1):375-378.
[3] 李敢,童昕,秦海燕,等.前牙区钛基台与氧化锆基台修复对种植体周围组织影响的短期评价[J].中国组织工程研究,2017,21(30): 4811-4816.
[4] 王玉增,单志华.羟基磷灰石(HAP)的制备及应用概况[J].皮革科学与工程,2015,25(6):34-38.
[5] CARVALHO O, SOUSA F, MADEIRA S, et al. HAp-functionalized zirconia surfaces via hybrid laser process for dental applications.Opt Laser Technol.2018;106:157-167.
[6] 鲍雨梅,徐哲玉,马龙,等.氧化锆增强HA涂层的制备及其磨损性能[J].中国陶瓷,2016,52(4):58-63.
[7] 沈倩倩,潘育松.生物功能梯度材料的制备技术及性能评价[J].热加工工艺,2015,44(14):21-24.
[8] 钱超,樊英姿,孙健.三维打印制备钛/羟基磷灰石复合体及功能梯度材料[J].中国组织工程研究,2013,17(29):5364-5370.
[9] EVANS C, TWEHEYO R, MCGARRY J, et al.What are the experiences of seeking, receiving and providing FGM-related healthcare.Perspectives of health professionals and women/girls who have undergone FGM:protocol for a systematic review of qualitative evidence.BMJ Open. 2017; 7(1):018-170.
[10] BAYATI R, MOLAEI R, RICHMOND A, et al.Modification of properties of yttria stabilized zirconia ep itaxial thin films by excimer laser annealing.ACS Appl Mater Inter. 2014;6(24): 22316-22325.
[11] TOMAN M, TOKSAVUL S, SARIKANAT M, et al.Fracture resistance of endodontically treated teeth:effect of tooth coloured post material and surface conditioning.Eur J Prosthodont Restor Dent.2010;18(1):23-30.
[12] DANILENKO I, LASKO G, BRYKHANOVA I, et al.The Peculiarities of Structure Formation and Properties of Zirconia-Based Nanocomposites with Addition of Al 2 O 3 and NiO.Nanoscale Res Lett.2017;12(1):125-130.
[13] MIAO Y, YANG Z, LIANG B, et al.A novel in situ synthesis of SiBCN-Zr composites prepared by a sol-gel process and spark plasma sintering.Dalton T.2016;45(32):12739-12744.
[14] WANG T, TSOI JK.A novel zirconia fibre-reinforced resin composite for dental use. J Mech Behav Biomed Mater. 2016; 53(5):151-160.
[15] LI X, YOSHIHARA K, DE MUNCK J, et al.Modified tricalcium silicate cement formulations with added zirconium oxide.Clin Oral Investig.2017;21(1):895-905.
[16] SPONCHIA G, MOSHTAGHIOUN BM, RIELLO P, et al. High-temperature compressive creep of novel fine-grained orthorhombic ZrO2 ceramics stabilized with 12 mol% Ta doping.J Eur Ceram Soc.2018;38(5):2445-2448.
[17] ZHOU C, DENG C, CHEN X, et al.Mechanical and biological properties of the micro-/nano-grain functionally graded hydroxyapatite bioceramics for bone tissue engineering.J Mech Behav Biomed Mater.2015;48(1):1-11.
[18] SANDOMIERSKI M, STRZEMIECKA B, CHEHIMI MM. Reactive Diazonium-Modified Silica Fillers for Polymers. Langmuir.2016;32(44):11646-11654.
[19] EWAIS EM, AMIN AM, AHMED YM, et al.Combined effect of magnesia and zirconia on the bioactivity of calcium silicate ceramics at C\S ratio less than unity.Mat Sci Eng C-Mater. 2017;70(2):155-160.
[20] 李清禄,李世荣.非保守功能梯度材料简支梁在过屈曲附近的振动响应[J].应用基础与工程科学学报,2019,27(1):95-103.
[21] MAHMOUDI M, SAIDI AR, HASHEMIPOUR MA.The use of functionally graded dental crowns to improve biocompatibility: a finite element analysis.Comput Methods Biomech Biomed Engin.2018;21(1):161-168.
[22] 李清禄,朱作权.陶瓷氧化锆和金属钛合金FGM变截面立柱的过屈曲数值模拟[J].功能材料,2017,48(2):2226-2230.
[23] BYKOV YV, EGOROV SV, EREMEEV AG, et al.Temperature profile optimization for microwave sintering of bulk Ni–Al2O3 functionally graded materials.J Mater Proc Tech. 2014;214(2): 210-216.
[24] BOLELLI G, BELLUCCI D, CANNILLO V, et al.Comparison between suspension plasma sprayed and high velocity suspension flame sprayed bioactive coatings.Surf Coat Tech. 2015;280(1):232-249.
[25] LIN D, LI Q, LI W, et al.Bone remodeling induced by dental implants of functionally graded material.J Biomed Mater Res B.2010;92(2):430-438.
[26] RAZA MR, SULONG AB, MUHAMAD N, et al.Effects of binder system and processing parameters on formability of porous Ti/HA composite through powder injection molding.Mater Design.2015;87(2):386-392.
[27] YOSHIHIKO H, KOUSUKE Z, HIDETOSHI F, et al.Fabrication and Compression Properties of Functionally Graded Copper Foam Made Using Friction Powder Sintering and Dissolution. J Mater Eng and Perform.2017;26(9).4508-4513.
[28] BAI D, LIU H, BAI H, et al.Powder metallurgy inspired low-temperature fabrication of high-performance stereocomplexed polylactide products with good optical transparency.Sci Rep-UK.2016;6(5):202-220.
[29] 万千.HA/316L不锈钢生物功能梯度材料的理化性能及体外生物活性研究[D].长沙:中南大学,2006.
[30] FERREIRA SC, CONDE A, ARENAS MA, et al.Anodization Mechanism on SiC Nanoparticle Matrix Composites Produced by Power Metallurgy.Mat.2014;7(12):8151-8167.
[31] 程西云,何俊,肖舒,等.梯度结构对氧化铝陶瓷涂层抗冲击载荷性能的影响[J].机械工程学报,2012,48(21):124-131.
[32] MARTELLI L, BERARDESCA E, MARTELLI M.Topical formulation of a new plant extract complex with refirming properties.Clinical and non-invasive evaluation in a double-blind trial.Inter J Cosmetic Sci.2008;22(3):424-430.
[33] FUJI T, TOHGO K, ARAKI H, et al.Fabrication and strength evaluation of biocompatible ceramic-metal composite material.J Solid Mech Mater Eng.2010;4(11):1699-1699.
[34] 冯晓娜,杨宪园,卢婷利,等.羟基磷灰石微载体的应用及制备[J].材料导报,2013,27(3):87.
[35] ALSAHHAF A, SPIES BC, VACH K.Fracture resistance of zirconia-based implant abutments after artificial long-term aging.J Mech Behav Biomed Mater.2017;66(4):224-232.
[36] 仇满德,王晓燕,李旭,等.水热法合成羟基磷灰石的微分析研究[J].人工晶体学报,2013,42(9):1965-1971.
[37] BHOWMICK A, PRAMANIK N, JANA P, et al.Development of bone-like zirconium oxide nanoceramic modified chitosan based porous nanocomposites for biomedical application.Int J Biol Macromol.2017,95(1):348-356.
[38] BERMÚDEZ-REYES B.Effect on growth and osteoblast mineralization of hydroxyapatite-zirconia(HA-ZrO2)obtained by a new low temperature system.Biomed Mater. 2018;13(3): 35-40.
[39] ZHANG L, HAN Y.Hydroxyaptite nanorods patterned ZrO2 bilayer coating on zirconium for the application of percutaneous implants.Colloid Surface B.2015;127(1):8-14.
[40] 史文涛,戴瑶,陈平波,等.鼻黏膜来源外胚间充质干细胞与磷酸钙骨水泥材料的体外相容性[J].中国组织工程研究,2018,22(33): 5350-5355.
[41] 刘宁,朱勇,刘昌奎,等.仿生磷酸钙缓释涂层改性三维支架的制备及性能研究[J].山西医科大学学报,2019,50(1):35-39.
[42] 陶剑,袁博,姜华.β-TCP/HA双相骨修复材料的Ames试验研究[J].生物骨科材料与临床研究,2013,10(5):1-4.
[43] KURTZ SM, DEVINE JN.PEEK biomaterials in trauma, orthopedic and spinal implants. Biomaterials. 2007;28(32): 4845-4869.