Physical factors and mechanisms affecting osteogenic ability of bone marrow mesenchymal stem cells

doi:10.3969/j.issn.2095-4344.2132

Abstract

Abstract:

BACKGROUND: To accelerate osteogenic differentiation, induce cell proliferation and in turn promote bone formation is considered to be an important research direction in the treatment of osseous diseases. Numerous studies have focused on looking for inducing factors that promote the osteogenic differentiation of bone marrow mesenchymal stem cells. To investigate the optimal conditions for inducing proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells has been an increasing concern.

OBJECTIVE: To review and discuss the effects of physical factors related to the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells and the possible mechanisms of signal transduction pathways.

METHODS: To search for articles on physical factors affecting osteogenic differentiation of bone marrow mesenchymal stem cell in WanFang, CNKI, PubMed, GeenMedical from June 2000 to November 2019, the search terms were “bone marrow mesenchymal stem cells, osteogenesis, differentiation” in Chinese and English, respectively. The old and repeated viewpoints were excluded, and finally 72 literatures were used for analysis.

RESULTS AND CONCLUSION: Relevant mechanical factors (such as compressive stress, shear stress, stretch stress, microgravity, low-frequency vibration), electromagnetic field, ultrasonic wave, electrical stimulation, and cold stimulation, have certain effects on the proliferation and osteogenic ability of bone marrow mesenchymal stem cells, which are realized through relevant factors and signaling pathways. However, their effects are influenced by the microenvironment of the transplant site, and some physical factors show a dual effect. Future investigation on the influencing factors with the optimal induction of bone marrow mesenchymal stem cells under different microenvironments as well as the mechanism of these factors will greatly promote the application of stem cells and the development of tissue engineering.

Key words: bone marrow mesenchymal stem cells, osteogenesis ability, physical factors, mechanical factors, stem cells, pathway

CLC Number:

Cui Xintao, Zhang Zhenyu. Physical factors and mechanisms affecting osteogenic ability of bone marrow mesenchymal stem cells[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(31): 5064-5070.

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