Chinese Journal of Tissue Engineering Research ›› 2017, Vol. 21 ›› Issue (34): 5532-5537.doi: 10.3969/j.issn.2095-4344.2017.34.020

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Numerical simulation of hemodynamics in a bioresorbable vascular scaffold

Zhang Ye-peng1, Zhou Min2, Tang Wen-hao1
  

  1. 1Southeast University Medical School, Nanjing 210009, Jiangsu Province, China; 2Department of Vascular Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China
  • Received:2017-07-01 Online:2017-12-08 Published:2018-01-04
  • Contact: Tang Wen-hao, Professor, Southeast University Medical School, Nanjing 210009, Jiangsu Province, China
  • About author:Zhang Ye-peng, Studying for master’s degree, Southeast University Medical School, Nanjing 210009, Jiangsu Province, China
  • Supported by:
    the Social Development Project of Jiangsu Provincial Science and Technology Department, No. BE2015603; the Medical Technology Development for the Excellent Youth in Nanjing City, No. JQX14002; the General Program of Nanjing Medical Technology Development, No. YKK16080

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Abstract:

BACKGROUND: Stent implantation cannot only cause an adaptive change of blood vessels, but also result in intravascular hemodynamic changes, including vascular wall shear stress and disturbance flow.
OBJECTIVE: To provide a theoretical basis for optimizing the stent design based on hemodynamics evaluation of the stented blood vessel by numerical simulation.
METHODS: Hemodynamics of the stented vessels were simulated by three-dimensional modeling, vessel-stent coupling, mesh partioning, boundary conditions setting. Then the trends of wall shear stress on six different vascular stent models were assessed and compared.
RESULTS AND CONCLUSION: The wall shear stress had the changing trend consistent with the inlet velocity. The wall shear stress was increased or decreased with the increase of decrease of inlet velocity, and reached or became close to the valley value when the inlet velocity was at valley value. This change rule was not affected by the structural change of the stent model. In the same stent model, the minimum wall shear stress at each point was less than 0.5 Pa, and these minimum values < 0.5 Pa lasted for different time in each cardiac cycle. In different stent models, the amount of points where the wall shear stress was less than 0.5 Pa in different cardiac cycles were in variety. To conclude, the wall shear stress at a point of the wall is positively correlated with the inlet velocity. During a cardiac cycle, at some time points, intimal hyperplasia is prone to occur in the region with the wall shear stress less than 0.5 Pa. Therefore, we should try to minimize the low wall shear stress region.

Key words: Graft Occlusion, Vascular, Hemodynamics, Tissue Engineering

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