Relationship between the gene polymorphisms of transforming growth factor beta 1 and interleukin 1 beta and primary knee osteoarthritis in Xinjiang Han and Uygur populations

doi:10.3969/j.issn.2095-4344.2017.24.023

Chinese Journal of Tissue Engineering Research ›› 2017, Vol. 21 ›› Issue (24): 3906-3911.doi: 10.3969/j.issn.2095-4344.2017.24.023

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Relationship between the gene polymorphisms of transforming growth factor beta 1 and interleukin 1 beta and primary knee osteoarthritis in Xinjiang Han and Uygur populations

Li Hai-tao^{1, 2}, Chen Fu-yu¹, Wang Wei-shan², Meng De-feng¹, Peng Jiang³, Lu Shi-bi³, Shi Chen-hui²

¹Shihezi University, Shihezi 832000, Xinjiang Uygur Autonomous Region, China; ²the First Affiliated Hospital of Shihezi University Medical School, Shihezi 832000, Xinjiang Uygur Autonomous Region, China; ³Key Laboratory of Chinese PLA, Institute of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China

Revised:2017-03-23 Online:2017-08-28 Published:2017-08-30
Contact: Wang Wei-shan, Associate professor, Chief physician, Master’s supervisor, the First Affiliated Hospital of Shihezi University Medical School, Shihezi 832000, Xinjiang Uygur Autonomous Region, China; Shi Chen-hui, Professor, Master’s supervisor, the First Affiliated Hospital of Shihezi University Medical School, Shihezi 832000, Xinjiang Uygur Autonomous Region, China
About author:Li Hai-tao, Master, Shihezi University, Shihezi 832000, Xinjiang Uygur Autonomous Region, China; the First Affiliated Hospital of Shihezi University Medical School, Shihezi 832000, Xinjiang Uygur Autonomous Region, China
Supported by:
the National Natural Science Foundation of China, No. 81360451 and 81660374; the Foundation for the Science and Technology Innovation Group of Corps, No. 2014CC002; the Foundation for the Young Leading Talent in Science and Technology Innovation of Corps, No. 2016BC001

Abstract

Abstract:

BACKGROUND: Transforming growth factor β1 (TGF-β1) and interleukin 1β (IL-1β) have been reported to play an important role in the occurrence and development of primary osteoarthritis.
OBJECTIVE: To investigate the association between gene polymorphisms of TGF-β1 and IL-1β and primary knee osteoarthritis.

METHODS: Han and Uyghur elderly populations in Xinjiang Uygur Autonomous Region, China were surveyed on the prevalence of osteoarthritis, followed by allotted to osteoarthritis and health groups according the symptoms and radiography. Genotyping TGF-β1 -509C/T and -1348C/T and IL-1β -511C/T was performed to analyze the relationship between the gene polymorphisms of TGF-β1 and IL-1β and osteoarthritis.

RESULTS AND CONCLUSION: Alleles T and C with genotypes CC, CT and TT were detected in both two groups. In the Uygur population, the genotype frequency of TGF-β1-509C/T and IL-1β-511C/T showed significant difference between osteoarthritis and health groups (P < 0.05). In the Han population, the genotype frequency of TGF-β1-1348C/T showed significant difference between two groups (P < 0.05). These results suggest that the Uygur individuals carrying TT genotype of TGF-β1-509C/T and IL-1β-511C/T, and Han people carrying the TT genotype of TGF-β -1348T are more susceptible to osteoarthritis.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Osteoarthritis, Knee, Transforming Growth Factor beta1, Interleukin-1beta;, Genes, Tissue Engineering

CLC Number:

R318

Li Hai-tao, Chen Fu-yu, Wang Wei-shan, Meng De-feng, Peng Jiang, Lu Shi-bi, Shi Chen-hui. Relationship between the gene polymorphisms of transforming growth factor beta 1 and interleukin 1 beta and primary knee osteoarthritis in Xinjiang Han and Uygur populations[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(24): 3906-3911.

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Relationship between the gene polymorphisms of transforming growth factor beta 1 and interleukin 1 beta and primary knee osteoarthritis in Xinjiang Han and Uygur populations

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