Effect of modified rabbit defensin 1 on peripheral nerve regeneration

doi:10.3969/j.issn.2095-4344.2017.24.011

Abstract

Abstract:

BACKGROUND: Peripheral nerve injury is a common disease in clinic, which severely affects the patients’ quality of life. How to promote peripheral nerve regeneration is an issue of concern.
OBJECTIVE: To study the effect of modified rabbit defensin 1 on peripheral nerve regeneration and functional recovery.
METHODS: Eighteen Sprague-Dawley rats were randomly divided into three groups. The rat sciatic nerves were transected and bridged by biodegenerated chitin conduits, followed by the injection of neurotrophic factor (group 1), modified rabbit defensin 1 (group 2) and normal saline (control group) into the gluteus, respectively, for consecutive 7 days.
RESULTS AND CONCLUSION: The sciatic nerve function index in the groups 1 and 2 was higher than that in the control group at 4 weeks postoperatively. The order of motor nerve conductive velocity was as follows: group 1 > group 2 > control group. The diameter regenerated fibers and axons, and the myelin thickness in the group 2 were less than those in the group 1, but were more than those in the control group. These results indicate that the modified rabbit defensin 1 can promote peripheral nerve regeneration, which may be related with the clearance of residual myelin by macrophages and the improvement in nerve regeneration environment.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Defensins, Macrophages, Tissue Engineering

CLC Number:

R318

Xu Chun-gui, Zhang Ji-sen, Xu Xin-zhong, Jing Jue-hua . Effect of modified rabbit defensin 1 on peripheral nerve regeneration[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(24): 3833-3838.

Figures/Tables 1

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