Gelatin sponge particles versus chitosan/alpha, beta-glycerophosphate gel microspheres in hemoptysis of pulmonary tuberculosis

doi:10.3969/j.issn.2095-4344.2017.18.015

Abstract

Abstract:

BACKGROUND: It is reported that gelatin sponge particles and chitosan/α, β-glycerophosphate gel microspheres have high application prospects in the treatment of hemoptysis of pulmonary tuberculosis.

METHODS: Forty SPF Kunming mice were selected to make animal models of pulmonary tuberculosis hemoptysis using aerosolized inhalation device and randomly divided into two groups undergoing embolization for hemostasis using gelatin sponge particles and chitosan/α, β-glycerophosphate gel microspheres, respectively. Body mass changes, hemostasis time, effective rate of hemostasis, related indexes of myocardium and pathological changes of pulmonary tuberculosis were observed at 15 and 30 days after treatment.

RESULTS AND CONCLUSION: (1) Mice in the chitosan/α, β-glycerophosphate gel microspheres group had higher body mass than those in the gelatin sponge group at 15 days after treatment (P < 0.05). (2) Compared with the gelatin sponge group, the hemostatic efficiency was higher and the time of hemostasis was shorter in the chitosan/α, β-glycerophosphate gel microspheres group (P < 0.05). (3) There were no significant differences in the levels of BNP precursor, creatine kinase isoenzyme and creatine kinase between the two groups (P > 0.05). (4) The lymphocyte infiltration and necrotic lesions were found around the microspheres, necrotic lesions were found, and there were a lot of active cells on the microspheres. There were a few lymphocytes in the gelatin sponge group. These results show that that the chitosan/α, β-glycerophosphate gel microspheres have better hemostatic effects in comparison with gelatin sponge particles in a mouse model of pulmonary tuberculosis.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Tuberculosis, Pulmonary, Gelatin Sponge, Absorbable, Chitosan, Tissue Engineering

CLC Number:

R318

Ji Ping, Chen Zhe, Sun Xiao-chen, Yuan Long. Gelatin sponge particles versus chitosan/alpha, beta-glycerophosphate gel microspheres in hemoptysis of pulmonary tuberculosis[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(18): 2876-2880.

Figures/Tables 5

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