Hemostatic effect of soluble hemostatic gauze on liver trauma in rabbits

doi:10.3969/j.issn.2095-4344.2016.47.011

Abstract

Abstract:

BACKGROUND: Modified cellulose dressing as an important part of polysaccharide hemostatic material has its unique advantages compared with gelatin sponge and fibrin glue.
OBJECTIVE: To compare the hemostatic effect and histocompatibility of medical gauze, absorbable hemostatic gauze and soluble hemostatic gauze.
METHODS: After establishment of liver trauma models, 36 New Zealand rabbits were randomly divided into three groups (n=12) depending on different hemostatic materials. Injury wounds were covered with soluble hemostatic gauze (mainly made of sodium carboxymethyl cellulose, experimental group), absorbable hemostatic gauze (mainly made of sodium carboxymethyl cellulose, control group) and medical gauze (normal group), respectively. The gauze was only taken out in the normal group. A hemostasis trial on liver injury was carried out to investigate the bleeding time and bleeding amount. After 1, 3, 7 and 10 days, wound healing was observed histologically in each group.
RESULTS AND CONCLUSION: The bleeding time and bleeding amount in the experimental and control groups were lower than those in the normal group (both P < 0.05), but no statistical difference was found between the experimental and control groups. After 1 day of implantation, the soluble hemostatic gauze was absorbed completely, and the absorbable hemostatic gauze was absorbed with no residual until the 10th day. Experimental and control groups shared similar pathological changes. In these two groups, mild fibrosis and fibrous scar appeared, a better improvement in wound inflammation was shown at 10 days compared with that at 7 days, and the wound gradually healed. In the normal group, there were no obvious lesions except mild tissue edema around the wound. All these findings suggest that the soluble hemostatic gauze has better hemostatic effect and histocompatibility.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Surgical Sponges, Hemostasis, Tissue Engineering

CLC Number:

R318

Liu Xiao-jun, Xu Yu-yin, Zhou Jing, Zhang Juan-li, Zhou Xiao-ting, Tian Yuan.

Hemostatic effect of soluble hemostatic gauze on liver trauma in rabbits

[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(47): 7070-7075.

Figures/Tables 2

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