In vivo osseointegration of micro-arc oxidation-silane-melatonin-covered titanium alloy implant

doi:10.3969/j.issn.2095-4344.2016.43.008

Abstract

Abstract:

BACKGROUND: Imperfect strength of titanium alloy implant-bone interface delays bone healing.
OBJECTIVE: In order to further improve the early healing ability of titanium dental implants, to make the surface modification of titanium alloy implant and observe the osseointegration ability of the implant.
METHODS: Titanium alloy implants were coated with micro-arc oxidation (group A), micro-arc oxidation-silane (group B), and micro-arc oxidation-silane-melatonin (group C) coatings, respectively. Three kinds of implants were placed into the mandible of New Zealand white rabbits, and 2, 4, 6 weeks after implantation, implant-bone interface osseointegration was observed using cone-beam CT, fluorescence microscopy, and torsion test.
RESULTS AND CONCLUSION: (1) Cone-beam CT examination: 6 weeks after implantation, the osseointegration of the implant with the mandible achieved the best results in the group C, followed by group B and group A. (2) Fluorescence microscope observation: the implants in the three groups exhibited the strongest fluorescence at 4 weeks and slightly weakened at 6 weeks, and the fluorescence intensity was higher in the group C than the other two groups. (3) Torsion test: with implantation time prolonged, the implant-bone osseointegration activity gradually increased in the three groups, while it was still highest in the group C (P < 0.05). In summary, our results show that the titanium alloy implant coated with micro-arc oxidation-silane-melatonin composite coating has higher osseointegration activity and promotes bone formation.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Dental Implants, Synostosis, Tissue Engineering

CLC Number:

R318

Li De-chao, Liu Hui-ping, Li Mu-qin, Liu Miao.

In vivo osseointegration of micro-arc oxidation-silane-melatonin-covered titanium alloy implant

[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(43): 6438-6444.

Figures/Tables 5

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