Porous titanium-niobium alloys with different porosities: biomechanical strength and cytocompatibility

doi:10.3969/j.issn.2095-4344.2016.38.013

Abstract

Abstract:

BACKGROUND: Titanium-niobium alloy holds high biomechanical strength and low elastic modulus that is close to the human cortical bone, so it has been extensively used as implant materials of dental, orthopedics and artificial hip joints.
OBJECTIVE: To observe the biomechanical strength and cytocompatibility of porous titanium-niobium alloys with different porosities.
METHODS: Porous titanium-niobium alloys with the porosity of 40% and 70% were prepared using powder metallurgy technology. Afterwards, the pore size, elasticity modulus and compressive strength of the two alloys were detected. Then the rabbit bone marrow mesenchymal stem cells were seeded onto the 40% and 70% porous titanium-niobium alloys, and cell adhesion and proliferation were observed at 3, 24 and 72 hours after inoculation, respectively.
RESULTS AND CONCLUSION: Pore size of porous titanium-niobium alloys with rough surface was 200-500 μm, and both main pore size was 350 and 400 μm, and there was three-dimensional connectivity between the pores; in the 70% group, honeycombed pores were partly fractured, and connected mutually; pores distributed unevenly and there was little communication between the pores in the 40% group. In addition, both groups had high compressive strength and low elastic modulus, but there was no difference between the two groups. Furthermore, both two alloys promoted cell adhesion, and the number of cell adhesion in the 70% group was significantly higher than that in the 40% group (P < 0.05), and extracellular matrix could be found in the 70% group. These results show that porous titanium-niobium alloy with the porosity of 70% is significantly conducive to cell adhesion.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Prostheses and Implants, Elasticity Modulus, Tissue Engineering

CLC Number:

R318

Wang Lei, Li Qiang.

Porous titanium-niobium alloys with different porosities: biomechanical strength and cytocompatibility

[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(38): 5709-5715.

Figures/Tables 6

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