Bio-safety of iodine-125 irradiated polyetheretherketone particle chain

doi:10.3969/j.issn.2095-4344.2016.38.014

Abstract

Abstract:

BACKGROUND: Polyetheretherketone (PEEK) has the potential to carry short-range radiations for cancer treatment. However, there is a lack of bio-safety assessment focusing on¹²⁵I irradiated PEEK particle chain.
OBJECTIVE: To evaluate bio-safety of the ¹²⁵I brachytherapy source irradiated PEEK particle chain.
METHODS: PEEK particle chain extracts were prepared according to GBT-16886 and applied in acute toxicity test on mice and rabbits, rabbit pyrogen test and rabbit intradermal reaction test. Animals in experimental, material and negative control groups were given irradiated PEEK particle chain extracts, non-irradiated PEEK particle chain extracts and extracts, respectively, to compare the experimental results.
RESULTS AND CONCLUSION: In mouse and rabbit acute toxicity test: irradiated PEEK particle chain extracts made no effects on the animal general conditions like breathing, activity, hair, secretion and body weight and morphology of the heart, liver, spleen, lung and kidney and other vital organs. In pyrogen test: the maximum temperature in three rabbits reached 0.4 ℃ (< 0.6 ℃), and the sum was 0.7 ℃ (< 1.3 ℃). In intradermal reaction test: the rabbit erythema and edema reaction scores both were 0. To conclude, ¹²⁵I irradiated PEEK particle chain exhibits a good bio-safety, presenting no acute toxicity, pyogen reaction and intradermal reaction.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Tissue Engineering, Biocompatible Materials, Iodine

CLC Number:

R318

Shi Feng, Chai Wen-wen, Zeng Li, Li Jun, Wang Cheng-kai.

Bio-safety of iodine-125 irradiated polyetheretherketone particle chain

[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(38): 5716-5721.

Figures/Tables 3

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