Vertebroplasty combined with anti-osteoporosis treatment reduces refracture rate

doi:10.3969/j.issn.2095-4344.2016.33.006

Abstract

Abstract:

BACKGROUND: Currently, vertebral compression fractures are the most common osteoporotic fracture in postmenopausal women; however, incidence of refracture has aroused increasing attention due to a lack of standard treatment.
OBJECTIVE: To evaluate whether vertebroplasty combined with anti-osteoporosis treatment can reduce refracture rate following osteoporotic vertebral compressive fractures.
METHODS: Eighty-nine patients with osteoporotic vertebral compressive fractures undergoing vertebroplasty were divided into control group (n=38) and treatment group (n=51) after making an informed choice about treatment. Chest/lumbar X-ray and bone mineral density determinations were performed through outpatient or inpatient follow-up. The spinal stability, bone mineral density and refracture rate of patients in both groups were followed up.
RESULTS AND CONCLUSION: Seventy-eight patients achieved complete follow-up (ranged from 6-39 months, average 26.73 months). There was no significant difference in the spinal stability between both groups (P > 0.05), while rare bone trabecula was found in the control group. There was a significant difference in bone mineral density between both groups at postoperative 12, 24, and 36 months (P < 0.05). The refracture rate in the treatment group was significantly lower than that in the control group (P < 0.05). Our results indicate that anti-osteoporosis treatment can effectively reduce the incidence of refracture after vertebroplasty in patients with osteoporotic vertebral compressive fractures, and this study found satisfactory short- and medium-term clinical outcomes.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Fractures, Compression, Osteoporotic Fractures, Vertebroplasty, Tissue Engineering

CLC Number:

R31.8

Yang Fu-guo, Yang Bo, Yin Biao, Li Shuang-qing, Yang Yi-xi, Gong Yi-xing. Vertebroplasty combined with anti-osteoporosis treatment reduces refracture rate[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(33): 4905-4912.

Figures/Tables 5

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