Changes in serum biomarkers of bone metabolism, Chemerin and hypoxia-inducible factor 1alpha in elderly men living on the plateau

doi:10.3969/j.issn.2095-4344.2016.33.002

Abstract

Abstract:

BACKGROUND: Increasing evidence suggests that the effects of hypoxia on the formation of osteoblasts are influenced by oxygen concentration and action time of hypoxia. However, very little is known regarding the changes in serum biomarkers of bone metabolism, Chemerin (an adipocyte-derived factor) and hypoxia-inducible factor 1α in elderly men living on the plateau.
OBJECTIVE: To investigate the changes in serum biomarkers of bone metabolism, Chemerin and hypoxia-inducible factor 1α, and to analyze the correlation of them in elderly men living on the plateau.
METHODS: A total of 162 Chinese Han elderly men living on the plateau were included and divided into
1 980 m group (n=83) and 3 300 m group (n=79). Levels of bone-specific alkaline phosphatase, tartrate-resistant acid phosphatase 5b, Chemerin, and hypoxia-inducible factor 1α in peripheral blood serum were determined by enzyme-linked immunosorbent assay.
RESULTS AND CONCLUSION: Serum levels of Chemerin and hypoxia-inducible factor 1α were significantly decreased (P < 0.05), while serum levels of bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase 5b were significantly increased (P < 0.05) in the 1 980 m group compared with the 3 300 m group. Serum levels of bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase 5b were negatively correlated with Chemerin and hypoxia-inducible factor 1α (P < 0.01). Our results suggest that hypoxia affects bone metabolism, Chemerin and hypoxia- inducible factor 1α in elderly men living on the plateau.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Alkaline Phosphatase, Hypoxia-Inducible Factor 1, alpha Subunit, Altitude Sickness, Tissue Engineering

CLC Number:

R318

Chen Liang, Xi Ai-qi, A Xiang-ren, Li Zi-an, Xi Kun, Peng Hai, Li Cheng-xiong, Wang Liang,Li Xiang. Changes in serum biomarkers of bone metabolism, Chemerin and hypoxia-inducible factor 1alpha in elderly men living on the plateau[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(33): 4876-4882.

Figures/Tables 4

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