Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (30): 4524-4531.doi: 10.3969/j.issn.2095-4344.2016.30.017

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Morpholine-2, 5-dione and its derivatives: the valuable biodegradable polymer materials

Zhou Qun-hua1, Yang Li-qun2, Zhang Wei2, Li Miao2   

  1. 1Zhengzhou Shuqing Medical College, Zhengzhou 450064, Henan Province, China; 2Liaoning Provincial Family Planning Research Institute, Key Laboratory of Reproductive Health and Medical Genetics, National Health and Family Planning Commission, Shenyang 110031, Liaoning Province, China
  • Received:2016-05-30 Online:2016-07-15 Published:2016-07-15
  • Contact: Yang Li-qun, Associate researcher, Liaoning Provincial Family Planning Research Institute, Key Laboratory of Reproductive Health and Medical Genetics, National Health and Family Planning Commission, Shenyang 110031, Liaoning Province, China
  • About author:Zhou Qun-hua, Lecturer, Zhengzhou Shuqing Medical College, Zhengzhou 450064, Henan Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 51503093; the Science Public Research Foundation of Liaoning Province, No. 2015001007; the Doctoral Scientific Research Foundation of Liaoning Province, No. 201501116; the Scientific Research Project of Shenyang, China, No. F16-205-1-37

Abstract:

BACKGROUND: Currently, biodegradable polymer materials such as poly(morpholine-2, 5-dione) and its derivatives have been widely used in biomedical field to fabricate nerve catheters, tissue engineering and drug control release carriers. Therefore, many research has focused on the synthesis of poly(morpholine-2, 5-dione) and its derivatives.
OBJECTIVE: To review the synthesis methods of monomeric and polymeric morpholine-2, 5-dione and its derivatives, and to explore its advantages and shortcomings.
METHODS: A computer-based search of databases of Wanfang, CNKI, SCI and PubMed was performed for relevant articles published from 1982 to 2015. And the keywords were “morpholine-2, 5-dion, biodegradable” in Chinese and English, respectively.
RESULTS AND CONCLUSION: So far, acylation reactions of α-amino acids and α-halogen halide, the intramolecular esterifications and intramolecular condensation reactions are the key methods for the synthesis of morpholine-2, 5-dione and its derivatives. A modified approach is needed to overcome the existed disadvantages. Ring-opening polymerization of morpholine-2, 5-dione is a preferred method of synthetic polyester-amide, but low molecular weight and conversion of polymers are produced. Polymerization catalyzed via metal compounds and enzymes are the best strategy for the synthesis of poly(morpholine-2, 5-dione). Furthermore, as a valuable biodegradable polymer material, poly(morpholine-2, 5-dione) has been extensively applied in the medical field.

Key words: Morpholines, Polymerization, Tissue Engineering

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