Stem cell transplantation protects the kidney in diabetic rat models

doi:10.3969/j.issn.2095-4344.2016.28.011

Abstract

Abstract:

BACKGROUND: So far numerous theoretical studies have shown the treatment effect of stem cell transplantation for chronic complications of diabetes, while its treatment effects on diabetic nephropathy have not yet been confirmed in animal models.
OBJECTIVE: To investigate the protective effect of bone marrow mesenchymal stem cell transplantation on the kidney in rat models of diabetes.
METHODS: Rats were fed with high-sugar and high-fat diet for 4 weeks, and then were given injection of streptozotocin to establish type 2 diabetic rat models. At 2 days after modeling, bone marrow mesenchymal stem cells were injected via the tail vein (stem cell transplantation group). In the meanwhile, control and diabetes groups were established. At 21 days after cell transplantation, levels of glucose, triglyceride and insulin in the tail vein were detected. Additionally, morphological observations of kidney and pancreatic tissues were performed.
RESULTS AND CONCLUSION: The levels of blood sugar, insulin and triglycerides in the diabetes group were significantly higher than those of the control group (P < 0.05). Blood glucose and insulin levels in the stem cell transplantation group were significantly lower than those of the diabetes group (P < 0.05). In addition, mesangial area and glomerular volume in the stem cell transplantation group were significantly lower compared with the diabetes group (P < 0.05). These results confirm that bone marrow mesenchymal stem cell transplantation can reduce levels of blood glucose and serum insulin, contributing to the repair of damaged pancreas and kidney.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Stem cells, Tissue Engineering, Diabetes Mellitus

CLC Number:

R394.2

Gan Li-ming. Stem cell transplantation protects the kidney in diabetic rat models[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(28): 4176-4181.

Figures/Tables 2

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