Intracoronary transplantation of umbilical cord blood stem cells reduces arrhythmia score and incidence of ventricular arrhythmia

doi:10.3969/j.issn.2095-4344.2016.23.015

Abstract

Abstract:

BACKGROUND: Until now, it is still unclear whether the stem cell transplantation triggers adverse effects on the myocardial electrical activity, resulting in the emergence of arrhythmia.
OBJECTIVE: To explore the effect of intracoronary transplantation of umbilical cord blood stem cells on arrhythmia score and incidence of ventricular arrhythmia.
METHODS: According to therapeutic strategies, 73 patients with coronary heart disease were assigned to receive drug therapy in control group (n=38) and umbilical cord blood stem cell transplantation in observation group (n=35). Arrhythmia score, incidence of ventricular arrhythmia and adverse reactions were recorded and analyzed before and 1, 4, 8 weeks after transplantation.
RESULTS AND CONCLUSION: After treatment, arrhythmia scores were significantly reduced in the two groups, especially in the observation group, to exhibit a continuous decline trend (P < 0.05). Compared with the control group, the incidence of ventricular arrhythmia was significantly lower in the observation (P < 0.05). However, there were no significant changes in the blood pressure, heart rate and blood oxygen saturation before and after transplantation, and no acute heart failure and death occurred in the two groups. These results suggest that the intracoronary transplantation of umbilical cord blood stem cells exhibits superiorities in the treatment of coronary artery disease, significantly reducing the arrhythmia score, reducing the incidence of ventricular arrhythmia, and resulting in less adverse reactions.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Stem Cells, Coronary Artery Disease, Cord Blood Stem Cell Transplantation, Tissue Engineering

CLC Number:

R394.2

Wang Cheng, Guo Chang-lei, Li Xia, Liu Zhen1, Han Ming-lei, Hou Yong-lan . Intracoronary transplantation of umbilical cord blood stem cells reduces arrhythmia score and incidence of ventricular arrhythmia[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(23): 3445-3450.

Figures/Tables 2

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