Peng Li-na, Jia Peng (College of Physical Education, Langfang Teachers University, Langfang 065000, Hebei Province, China)

doi:10.3969/j.issn.2095-4344.2016.18.019

Abstract

Abstract:

BACKGROUND: Studies have shown that Maca can enhance immune cell function, improve mitochondrial respiratory chain enzymes, and play a role in anti-oxidation and anti-aging.
OBJECTIVE: To observe Maca effects on kidney mitochondrial respiratory function and anti-aging capabilities in elderly rats after exhausted exercise.
METHODS: 10-month-old elderly rats were intragastrically administrated Maca powder 5 g/kg, once a day, and did treadmill exercise, 5 days in a week. Rats were randomly divided into control group, Maca group and training group and Maca+training group. At 6 weeks after training, rats in each group did exhausted exercise (35 m/min), and immediately received intraperitoneal injection of 2% sodium pentobarbital. The kidney was obtained, and mitochondria were extracted by differential centrifugation. A spectrophotometer was used to measure mitochondrial respiratory chain activity.
RESULTS AND CONCLUSION: (1) Mitochondrial respiratory chain enzyme and antioxidant enzyme activity: mitochondrial respiratory chain enzyme I-III, superoxide dismutase and glutathione peroxidase activities were higher in the Maca+training group than in the control group, Maca group and training group (P < 0.05 or P < 0.01), but malondialdehyde content was lower (P < 0.05 or P < 0.01). (2) Results suggested that the combination of supplement Maca and incremental exercise can improve mitochondrial respiratory function and delay aging in the kidney of aged rats after exhausted exercise. Moreover, supplemented Maca and incremental exercise have a synergistic effect.
中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

Key words: Tissue Engineering, Models, Animal, Mitochondria

Peng Li-na, Jia Peng. Peng Li-na, Jia Peng (College of Physical Education, Langfang Teachers University, Langfang 065000, Hebei Province, China)[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(18): 2711-2716.

Figures/Tables 2

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