Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (15): 2273-2280.doi: 10.3969/j.issn.2095-4344.2016.15.020

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Application and progress in endothelial progenitor cells in hypertension

Li Wen-hua, Zhang Qun-hui, Rong Hao, Cai Peng, Yuan Dong-ya   

  1. Medicine School of Xizang Minzu University, Xianyang 712082, Shaanxi Province, China
  • Received:2016-01-16 Online:2016-04-08 Published:2016-04-08
  • Contact: Yuan Dong-ya, Professor, Medicine School of Xizang Minzu University, Xianyang 712082, Shaanxi Province, China
  • About author:Li Wen-hua, Professor, Medicine School of Xizang Minzu University, Xianyang 712082, Shaanxi Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81360299

Abstract:

BACKGROUND: Structural and functional changes of endothelial cells are the common pathological basis of cardiovascular disease. Severe structural and functional damage of endothelial cells are found in patients with hypertension or coronary heart diseases.

OBJECTIVE: To explore a new treatment method for hypertension from the perspective of vascular endothelial progenitor cells.
METHODS: PubMed and Wanfang databases were retrieved using the keywords “hypertension, EPCs” and approximately relevant 200 English and 100 Chinese literatures were obtained. Forty-nine eligible literatures were screened finally.
RESULTS AND CONCLUSION: Endothelial progenitor cells have strong differentiation and proliferation capacities. This review may provide a new insight into potential sources of cells for diagnosis and treatment of hypertension.
中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程

Key words: Endothelial Cells, Hypertension, Tissue Engineering