Comparison of conventional and new mesh hydroxyapatite in repair of cleft lip and palate

doi:10.3969/j.issn.2095-4344.2015.47.015

Abstract

Abstract:

BACKGROUND: Despite regular mesh hydroxyapatite has certain biocompatibility and bone conductivity, it cannot be absorbed by human body after transplantation, and will affect the growth and eruption of maxilla and fangs when using for filling the injured alveolar cleft.

OBJECTIVE: To compare the effect of conventional and new mesh hydroxyapatite composites in repair of alveolar cleft defects.

METHODS: Totally 46 patients with cleft lip and palate were randomly and evenly divided into test and control groups, and all were arranged according to cleft lip and palate sequence treatment. After nasal soft tissue defect repair, new mesh hydroxyapatite composite bone material (hydroxyapatite and bone morphogenetic protein compound). Conventional mesh hydroxyapatite material was adopted in the test and control groups, respectively. Within 6 months after the repair, the vertical distance from the newly formed bone tissue plane to the top of alveolar ridge was observed. The clinical repair effect was comprehensively evaluated from the aspects of complications, alveolar cleft shape and size, callus formation and material absorption.

RESULTS AND CONCLUSION: At 2, 4, 8, 12 and 24 weeks, the vertical distance from the newly formed bone tissue plane to the top of alveolar ridge in the test group was higher than that in the control group (P < 0.05). The clinical repairing significant efficiency and total effective rate were all higher than those in the control group

(P < 0.05). These results show that new mesh hydroxyapatite composite bone materials in the repair of alveolar cleft defects have good bone osteoinductivity and biocompatibility, rare complications and rapid callus formation.
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Durapatite, Bone Morphogenetic Proteins, Alveolar Process, Tissue Engineering

Yu Wei, Feng Hong-chao. Comparison of conventional and new mesh hydroxyapatite in repair of cleft lip and palate[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(47): 7629-7633.

Figures/Tables 3

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