Mesenchymal stem cells in the inflammatory immunomodulation

doi:10.3969/j.issn.2095-4344.2015.45.026

Abstract

Abstract:

BACKGROUND: Studies have shown that the main functions of mesenchymal stem cells include direct participation in wound healing, growth factor secretion, promoting angiogenesis, immune regulation and inflammation, anti-oxidative stress, which can be used to treat a variety of acute and chronic diseases.
OBJECTIVE: To review advances in mesenchymal stem cells in the inflammatory immunomodulation.
METHODS: A computer-based search of Wanfang, CNKI and PubMed databases was performed for articles concerning advances in mesenchymal stem cells in the inflammatory immunomodulation published from January 2005 to August 2015. The search terms were “stem cells, mesenchymal stem cells, immune regulation, inflammation, immune cells, inflammatory factors, treatment” in Chinese and English, respectively. Finally, 40 articles were included in result analysis.
RESULTS AND CONCLUSION: Because of their immunomodulation and muti-directional differentiation, mesenchymal stem cells garner increasing attentions. In addition, mesenchymal stem cells can be harvested from different tissues and have good in vitro amplification capability, which have a broad prospect in the clinical use, including tissue repair and anti-inflammation. As the most promising cells used clinically, mesenchymal stem cells show their superiority in the treatment of many diseases, especially in inflammations induced by immune modulation imbalance. We believe that mesenchymal stem cells will play an important role in the future cell biotherapy.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Mesenchymal Stem Cell Transplantation, Immunomodulation, Inflammasomes, Tissue Engineering

Zheng Sheng, Yang Juan, Tang Ying-mei. Mesenchymal stem cells in the inflammatory immunomodulation [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(45): 7362-7368.

Figures/Tables 1

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