Periodontal ligament stem cell differentiation and proliferation in periodontal tissue regeneration

doi:10.3969/j.issn.2095-4344.2015.45.027

Abstract

Abstract:

BACKGROUND: Periodontal ligament stem cells are one of the ideal seed cells in periodontal tissue regeneration. Sources, biological characteristics and influential factors of periodontal ligament stem cells have been an issue of concern.
OBJECTIVE: To review the biological characteristics and functional factors of periodontal ligament stem cells as well as relevant research status and progress in regenerative medicine, and to discuss the relevant application prospect and existing problems, thereby providing theoretical and experimental basis.
METHODS: PubMed and Wanfang databases were searched by the first author for articles related to differentiation and proliferation of periodontal ligament stem cells published from 2002 to 2015. The key words were “periodontal ligament stem cell, periodontal tissue, proliferation, differentiation” in English and Chinese, respectively. Finally, 47 articles were included in result analysis.
RESULTS AND CONCLUSION: Periodontal ligament stem cells have the ability of differentiating into fibroblasts, adipocytes, chondrocytes and cementum. Cell growth factors play an important role in the proliferation and differentiation of periodontal ligament stem cells. Fibroblast growth factor, vascular endothelial growth factor and insulin-like growth factor can promote the proliferation of periodontal ligament stem cells. Application of stem cell biofilm as a carrier material can effectively guide periodontal tissue regeneration. Isolation, culture and influential factors of periodontal ligament stem cells should be further improved. Combined application of stem cells, biofilms and growth factors is expected to achieve the desired periodontal tissue regeneration, which is the focus of future research.
中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Stem Cells, Periodontal Ligament, Cell Proliferation, Guided Tissue Regeneration, Periodontal, Tissue Engineering

Zhu Ling-lan, Xu Sheng-min. Periodontal ligament stem cell differentiation and proliferation in periodontal tissue regeneration[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(45): 7369-7373.

Figures/Tables 1

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