Preparation and biomedical application of superparamagnetic iron oxide

doi:10.3969/j.issn.2095-4344.2015.43.028

Abstract

Abstract:

BACKGROUND: Superparamagnetic iron oxide has been widely used in biomedical applications, especially in the field of targeted diagnosis and therapy.

OBJECTIVE: To summarize the physicochemical property, preparation, surface modification, product testing and biomedical applications of superparamagnetic iron oxide.

METHODS: In order to search relevant articles about the physicochemical property and biomedical applications of superparamagnetic iron oxide from PubMed, Sciencedirect, CNKI and Wanfang databases (from 2000 to 2014), a computer-based search was performed using the keywords of “superparamagnetic iron oxide, preparation, coprecipitation, surface modification, magnetic resonance imaging contrast agent, fluorescent tracing, targeted therapy” in English and Chinese, respectively.

RESULTS AND CONCLUSION: The superparamagnetic iron oxide can be produced in the laboratory, and the preparation methods include hydrothermal method, vapor deposition method, mechanical milling method, liquid-phase microwave dielectric heating method, sol-gel method, emulsion method, co-precipitation method. Moreover, the superparamagnetic iron oxide can have different properties by surface modification and be applied in many biomedical fields, such as magnetic resonance contrast agent, fluorescent tracer, nanoparticle targeted therapy, hyperthermia and bioseparation.
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Nanoparticles, Biomedical Technology, Tissue engineering

Chen Zhu, Shang Quan-liang, Xiao En-hua. Preparation and biomedical application of superparamagnetic iron oxide[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(43): 7041-7046.

Figures/Tables 2

References

[1] Bowman K,Leong KW.Chitosan nanoparticles for oral drug and gene delivery.Int J Nanomedicine.2006;1(2): 117-128.

[2] Cheng FY,Su CH,Yang YS,et al.Characterization of aqeous dispersions of Fe3O4 nanoparticles and their biomedical applications.Biomaterials.2005;26(7):729-738.

[3] 麦筱莉,滕皋军,马占龙,等.纳米磁粒子复合特标记对内皮祖细胞生物学特性影响的实验研究[J].中华放射学杂志,2008,42(7): 758-764.

[4] Le Renard PE,Lortz R,Senatore C,et al.Magnetic and in vitro heating properties of implants formed in situ from injectable formulations and containing superparamagnetic iron oxide nanoparticles (SPIONs) embedded in silica microparticles for magnetically induced local hyperthermia.J Magn Magn Mater. 2011;323:1054-1063.

[5] 邹芬,潘一峰,张红,等.聚乙二醇-聚乙烯亚胺/四氧化三铁纳米磁流体的毒性及其生物相容性[J].中国组织工程研究与临床康复, 2010,14(3):447-451.

[6] Rosen JE,Chan L,Shieh DB,et al.Iron oxide nanoparticles for targeted cancer imaging and diagnostics.Nanomedicine. 2012; 8(3):275-290.

[7] Tassa C,Shaw SY,Weissleder R.Dextran-coated iron oxide nanoparticles：a versatile platform for targeted molecular imaging，molecular diagnostics and therapy.Acc Chem Res.2011;44(10):842-852.

[8] Gupta AK,Gupta M.Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles.Biomaterials.2005;26(13):1565-1573.

[9] 于莉莉,庄家琪,张惠茅.磁性氧化铁纳米粒子造影剂在MRI 应用进展[J].中国实验诊断学,2011,15(12):2184-2186.

[10] 贺娟,贾延会,邓均,等.甘露醇修饰超顺磁纳米颗粒的制备及体外特性分析[J].第三军医大学学报,2011,33(15):1586-1589.

[11] 李黎,马力.Fe₃O₄磁性微粒的制备及表征[J].中国组织工程研究与临床康复,2011,15(34):6385-6387.

[12] Woo K,Hong J,Choi S,et al.Easy Synthesis and Magnetic Properties of Iron Oxide Nanoparticles.Chem Mater.2004; 16(14):2814-2818.

[13] Neuberger T,Schopf B,Hofmann H,et al.Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system.J Magn Magn Mater. 2005;293(1):483-496.

[14] Laurent S,Forge D,Port M,et al.Magnetic iron oxide nanoparticles: synthesis stabilization,vectorization, physicochemical characterizations,and biological applications. Chem Rev.2008;108(6):2064-2110.

[15] 彭健,唐琦,潘一峰,等.Fe3O4空心磁纳米微球制备工艺条件的影响因素[J].中国组织工程研究与临床康复,2010,14(25): 4614-4618.

[16] 孙鹏飞,颉克蓉,张锋伟,等.生物相容性Fe3O4@SiO₂纳米粒子的合成及性能[J].中国组织工程研究与临床康复,2011,15(51): 9579-9582.

[17] Kawaguchi T,Hasegawa M.Structure of dextran-magnetic complex relation between conformation of dextran chains covering core and its molecular weight.J Mater Sci Mater Med. 2000;11(1):31-35.

[18] Lu AH,Salabas EL,Schüth F.Magnetic nanoparticles:synthesis. proteetion,functionalization,and application.Angew Chem Int Ed Engl.2007;46(8):1222-1244.

[19] Tartaj P,Morales MDD,Veintemillas-Verdaguer S,et al.The preparation of magnetic nanoparticles for applications in biomedicine.J Phys D Appl Phys.2003;36:182-197.

[20] Fang LM.Synthesis and characteristics of Fe3+-doped SnO2 nanoparticles via sol-gel-calcination or sol-gel-hydrothermal route.J Alloys Compd. 2008;454(l-2):261-267.

[21] 刘骏.沉淀氧化法制备Fe3O4磁流体[J].武汉工业学院学报, 2009,28(2):42-44.

[22] R Fan,XH Chen,Z Gui,et al.A new simple hydrothermal preparation of nanocrystalline magnetite Fe3O4.Mater Res Bull.2001;36:497-502.

[23] Boutonnet M,Kizling J,Stenius P,et al.The preparation of monodisperse colloidal metal particles from microemulsions.Colloids and Surfaces.1982;5(3):209-225.

[24] Yamaura M,Camilo R,Sampaio L,et al.Preparation and characterization of (3-aminopropyl) triethoxysilane-coated magnetite nanoparticles.J Magn Magn Mater.2004;279(2): 210-217.

[25] Gao J,Gu H,Xu B.Multifunctional magnetic nanoparticles: design, synthesis,and biomedical applications.Acc Chem Res.2009;42(8):1097-1107.

[26] Li Y1,Ding MJ,Wang S,et al.Preparation of imprinted polymers at surface of magnetic nanoparticles for the selective extraction of tadalafil from medicines.ACS Appl Mater Interfaces.2011;3(9):3308-3315.

[27] 刘祖黎,杜玉卿,胡道予,等.超小型超顺磁性氧化铁磁共振对比剂的制备及性能研究[J].功能材料,2005,36(3):350-356.

[28] Chastellain M,Petri A,Hofmann H.Particle size investigations of a multistep synthesis of PVA coated superparamagnetic nanoparticles.J Colloid Interface Sci. 2004;15(2):353-360.

[29] 刘世霆,晏媛,陈志良,等.超顺磁性葡聚糖氧化铁纳米颗粒的研制及表征[J].南方医科大学学报,2006,26(3):331-334.

[30] Chen XH ,Brady M,Lo JL,et al.Simultaneous segmentation and registration of contrast-enhanced breast MRI.Inf Process Med Imaging.2005;19:126-137.

[31] Klerkx WM,Bax L,Veldhuis WB,et al.Detection of lymph node metastases by gadolinium-enhanced magnetic resonance imaging:systematic review and meta-analysis.J Natl Cancer Inst.2010;102(4):244-253.

[32] Omary RA,Henseler KP,Unal O,et al.Validation of injection parameters for catheter-directed intraarterial gadolinium-enhanced MR angiography.Academic Radiology, 2002;9(2):172-185.

[33] Karadeniz-Bilgili MY,Braga L,Birchard KR,et al.Hepatocellular carcinoma missed on gadolinium enhanced MR imaging, discovered in liver explants:retrospective evaluation.J Magn Reson Imaging.2006;23(2):210-215.

[34] Chrysochou C,Power A,Shurrab AE,et al.Low risk for nephrogenic systemic fibrosis in nondialysis patients who have chronic kidney disease and are in vestigated with gadolinium-enhanced magnetic resonance imaging.Clin J Am Soc Nephrol.2010;5(3):484-489.

[35] 赵江民,刘佳,林雁冰,等.SPIO标记浓度对BMSCs生物学特性的影响及体外MRI表现[J].磁共振成像,2014,5(2):138-143.

[36] Berry CC,Curtis ASG.Functionalisation of magnetic nanoparticles for applications in biomedicine.J PhysD Appl Phys.2003;36(13):198.

[37] Mulder WJ,Strijkers GJ,van Tilborg GA, et al.Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging.NMR Biomed.2006;19(1):142-164.

[38] Jaganathan H,Hugar DL,Ivanisevic A.Examining MRI contrast in three-dimensional cell culture phantoms with DNA-templated nanoparticle chains.ACS Appl Mater Interfaces. 2011;3(4):1282-1288.

[39] Gao J, Zhang W,Huang P,et al.Intracellular spatial control of fluorescent magnetic nanoparticles.J Am Chem Soc.2008; 130(12):3710-3711.

[40] Kircher MF,Mahmood U,King RS,et al.A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation.Cancer Res.2003;63(23):8122-8125.

[41] Shen J,Sun LD,Zhang YW,et al.Superparamagnetic and upconversion emitting Fe3O4/NaYF4:Yb,Er hetero-nanoparticles via a crosslinker anchoring strategy. Chem Commun.2010;46:5731.

[42] 文曦琳,李易,葛晓东,等.SPIO-PLL-pshRNA分子探针转染卵巢癌SKOV3细胞及MR成像研究[J].重庆医科大学学报,2014, 39(4): 506-510.

[43] Widder KJ,Senyel AE,Scarpelli GD.Magnetic microspheres: a model system of site specific drug delivery in vivo.Proc Soc Exp Biol Med.1978;158(2):141-146.

[44] Lübbe AS,Alexiou C,Bergemann C.Clinical applications of magnetic drug targeting.J Surg Res.2001;95(2):200-206.

[45] Alexiou C,Arnold W,Klein RJ,et al.Locoregional cancer treatment with magnetic drug targeting.Cancer Res.2000; 60(23):6641-6648.

[46] Chomoucka J,Drbohlavova J,Huska D,et al.Magnetic nanoparticles and targeted drug delivering.Pharmacol Res. 2010;62(2):144-149.

[47] 陈月,陈宝安.磁性氧化铁纳米颗粒在肿瘤靶向治疗中的应用及进展[J].癌症,2010,29(1):125-128.

[48] Foy SP,Manthe RL,Foy ST,et al.Optical imaging and magnetic field targeting of magnetic nanoparticles in tumors.ACS Nano. 2010;4(9):5217-5224.

[49] Dong X,Zheng Y,Huang Y,et al.Synthesis and characterization of multifunctional poly(glycidyl methacrylate) microspheres and their use in cell separation.Anal Biochem.2010;405(2): 207-212.