Application of tissue engineering scaffolds in neural repair

doi:10.3969/j.issn.2095-4344.2015.43.027

Abstract

Abstract:

BACKGROUND: Tissue engineering scaffolds can create proper nerve regeneration microenvironment, enrich nutritional factors for nerve regeneration and promote axonal growth.

OBJECTIVE: To review the progress of tissue engineering scaffolds in nerve repair in recent years.

METHODS: A computer-based retrieval was performed to search full-text articles addressing tissue engineering scaffolds used to repair nerve damage published from 2009 to 2014 in PubMed databases using the keywords of “nerve regeneration, prostheses and implants” as well as articles published from 2004 to 2014 in CNKI database using the keywords of “nerve repair, material” in Chinese.

RESULTS AND CONCLUSION: Currently, scaffold materials for nerve damage mainly include natural materials, naturally derived materials, synthetic materials and composites, all of which have their own advantages and disadvantages. By chemical crosslinkers or chemical modification, the naturally derived polymer can be combined with other natural or synthetic composite materials, to improve their physicochemical and biological properties, i.e., the composite scaffolds have better effects than single materials in nerve regeneration. Therefore the current research focus is composite materials. In clinical research, collagen scaffold for nerve repair has entered the clinical research stage.
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Tissue Engineering, Silk

Han Qian-qian, Wang Peng-rui, Wang Chun-ren, Yang Zhao-peng, Wang Hong. Application of tissue engineering scaffolds in neural repair[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(43): 7035-7040.

Figures/Tables 2

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