Structural properties influence the osteoinduction of calcium phosphate ceramics

doi:10.3969/j.issn.2095-4344.2015.43.023

Abstract

Abstract:

BACKGROUND: Currently, the mechanism by which calcium phosphate ceramics induces osteogenesis is not fully understood, and many scholars have tried to expound the mechanism from the perspective of the structural properties.

OBJECTIVE: To review how the structural properties of calcium phosphate ceramics affect their osteoinductive activity.

METHODS: The PubMed database and Google academic database (1997-01/2015-03) were searched to retrieve the related articles about the structural properties of calcium phosphate ceramics affecting their osteoinductive activity. After the articles with outdated reviews or repetitive contents were ruled out, 60 articles were suitable for further analysis and review.

RESULTS AND CONCLUSION: The structural properties of calcium phosphate ceramics are displayed by macrostructure, such as macropores, holes, pipes and space between particles, and microstructure, such as micropore, particle size, surface roughness, specific surface area. Each parameter of the structural properties affects the bioactivities of calcium phosphate ceramics in some way, which renders their abilities of inducing osteogenesis to arise from nothing or change from weakly to strongly. Apart from structure design, physical and chemical properties of calcium phosphate ceramics will also affect its biological activity in vivo. Therefore, the physicochemical properties of calcium phosphate ceramics should be considered in the structure design in order to achieve an optimal osteoinductive activity.
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Calcium Phosphates, Ceramics, Tissue Engineering

Meng Lei, Zhen Ping, Liang Xiao-yan, Cao Xue-fei. Structural properties influence the osteoinduction of calcium phosphate ceramics[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(43): 7010-7016.

Figures/Tables 2

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