Maxillofacial and periodontal tissue-engineered bone: vascularization and osteogenesis strategies

doi:10.3969/j.issn.2095-4344.2015.42.018

Abstract

Abstract:

BACKGROUND: Maxillofacial bone and periodontal tissue defect is one of the important diseases that affect human functionality and aesthetic appearance, and bone tissue engineering becomes the main means to repair maxillofacial and periodontal tissue defects. Currently, the basic mode is constructed by the combination of co-culture of seed cells and cells, scaffolds and micro-environment. Pre-vascularization and rapid osteogenesis of tissue-engineered bone can reduce implant necrosis and absorption, and improve repair success rate.
OBJECTIVE: To summarize the new progress of bone tissue engineering used in the oral and maxillofacial and periodontal tissue in the past 5 years.
METHODS: CNKI database and PubMed database from 2010 to 2015 were searched using the keywords of “oral and maxillofacial, bone tissue engineering, bone regeneration, vascularization, genetic modification, seed cells, support material, microenvironment” in Chinese and English, respectively. After elimination of independent and repetitive studies, 68 articles were included in result analysis.
RESULTS AND CONCLUSION: The tissue-engineered bone has achieved tremendous progress in the repair of oral and maxillofacial and periodontal tissue defects. The three-dimensional scaffold with gene-modified seed cells can effectively promote the vascularization, improve the osteogenic effect and increased the probability of success in mandibular defect repair. In addition, tissue-engineered bone implantation into the alveolar ridge defects or fresh extraction fossa can effectively restore and preserve alveolar ridge height and width, to ensure a good bone condition for subsequent restorative treatment. After the implantation of tissue-engineered bone, different external environmental stimuli could be loaded at defect sites, and the extracellular matrix components or signal pathway could be adjusted to change the process of vascularization. Vascularization is a premise condition for the establishment of an effective blood circulation to ensure the success of scaffold implantation.
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Tissue Engineering, Jaw, Periodontium, Neovascularization, Physiologic

Zhang Xin-yue, Li Yan, Li Chen-jun. Maxillofacial and periodontal tissue-engineered bone: vascularization and osteogenesis strategies[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(42): 6819-6825.

Figures/Tables 1

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