Fabrication and functional characteristics of cardiac patches

doi:10.3969/j.issn.2095-4344.2015.38.026

Abstract

Abstract:

BACKGROUND: In recent years, a lot of studies have reported the feasibility and efficacy of transplanting seed cells via tissue-engineered cardiac patches into specific infarcted myocardial area, helping regeneration of damaged heart tissue and improving heart functions.
OBJECTIVE: To review the methods and strategies of fabricating tissue-engineered cardiac patches and to analyze the structure and functional characteristics of cardiac patches prepared by different methods.
METHODS: The first author retrieved relevant articles about the fabrication methods of tissue engineered cardiac patches by searching PubMed and Web of science data bases. The key words were “cardiac infarction, cell death”.
RESULTS AND CONCLUSION: The fabrication methods and strategies of tissue-engineered cardiac patches are as follows: (1) obtaining multi-layer cell sheets by overlapping monolayer cell sheets; (2) combing gelatin with cells to construct multi-layer cell sheets; (3) seeding cells on scaffolds; (4) homogeneous arrangement of cells. Recent studies about tissue-engineered cardiac patches have demonstrated that the biological activities of seed cells, such as retention, survival and paracrine effects, greatly influence the effect of cardiac patches on the repair and regeneration of infarcted myocardial tissues. Temperature-sensitive method is the most mature and wide-spread used constructing technique; besides, other strategies also successfully improve the biological activities of seed cells to different extents, and they also increase the mechanical strength and thickness of cell

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: 生物材料, 材料相容性, 心肌补片, 组织工程, 心肌梗死, 构建方法

CLC Number:

R318

Wang Ying-wei, Qin Zi-xi, Wu Zheng. Fabrication and functional characteristics of cardiac patches [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(38): 6211-6216.

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