Chinese patent of anti-infective urinary catheter

doi:10.3969/j.issn.2095-4344.2015.25.029

Abstract

Abstract:

BACKGROUND: Catheter associated urinary tract infection is a difficult problem for clinical practice management, and its key pathogenesis is the bacterial biofilm formation on the surface of the catheter material. Therefore, developing a new anti-infective urinary catheter has become an area of interest in the current studies of anti-infective biological materials.

OBJECTIVE: To review the research literatures on anti-infective urinary catheter, and provide a direction for further study and clinical application.

METHODS: All related Chinese patent papers of anti-infective urinary catheters were retrieved by Google’s proprietary search platform (http://www.google.com/advanced_patent_search) until the deadline of March 26, 2014, with the search strategy of ‘Return the patents with the following proprietary name: urinary catheter’.

RESULTS AND CONCLUSION: According to the predefined search strategy, 949 potentially relevant patent papers were screened out for further identification, and 23 papers referred to anti-infective catheters that were obviously eligible were included. The analyses showed that: (1) The antibacterial coating agents of the majority of papers were antibacterial agents of nano-inorganic metal cations, only four papers used antibiotic coated. (2) The drug-eluting catheters were mainly composite-coated. (3) The drug release modes from coating were mainly extended-release but release mechanism was not clarified. (4) The preparation process was chemical bond or ionic bond in one paper, blending methods in one paper, repeated electroplating in one paper, electrospinning technology in one paper, and physical impregnation methods in 12 papers (52.17%). (5) The antimicrobial mode was ultrasonic-antibacterial method in two patent papers, sterile sleeve in one paper, hydrophilic coating in one paper, catheter made by blending polymer material and anti-infective agents in one paper, drug coated films made by coating with antimicrobial drug liquid and drying process in 20 papers (82.61%). In conclusion, there have been no translational and applied clinical researches about the anti-infective urinary catheter, and the relevant researches were only at the laboratory level. The research methods of Chinese patent for anti-infective urinary catheter were limited, and need to be further improved.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: 生物材料, 材料相容性, 导管相关尿路感染, 抗感染尿管, 专利, 综述

CLC Number:

R318

Xiong Guo-bing, Wang Yu, Qiu Ming-xing. Chinese patent of anti-infective urinary catheter[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(25): 4086-4090.

Figures/Tables 3

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