Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (34): 5523-5529.doi: 10.3969/j.issn.2095-4344.2015.34.022

Previous Articles     Next Articles

Three-dimensional tissue engineering scaffolds based on graphene

Wang Xin1, 2, Li Peng1, Wang Zan3, Xu Hai-feng2, Dong Fu-ping2, Chen Hao1, Jiang Hong-yu3Klaud D Jandt2   

  1. 1College of Materials Science and Engineering, Key Laboratory of Automobile Materials of MOE, Jilin University, Changchun 130012, Jilin Province, China; 2Materials Science, Otto Schott Institute for Materials Research, Friedrich Schiller University Jena, Löbdergraben 32, 07743 Jena, Germany; 3Department of Neurology, the First Bethune Hospital at Jilin University, Changchun 130021, Jilin Province, China
  • Online:2015-08-20 Published:2015-08-20
  • Contact: Jiang Hong-yu, Professor, Doctoral supervisor, Department of Neurology, the First Bethune Hospital at Jilin University, Changchun 130021, Jilin Province, China
  • About author:Wang Xin, Dr., Professor, College of Materials Science and Engineering, Key Laboratory of Automobile Materials of MOE, Jilin University, Changchun 130012, Jilin Province, China; Materials Science, Otto Schott Institute for Materials Research, Friedrich Schiller University Jena, L?bdergraben 32, 07743 Jena, Germany
  • Supported by:

    the Outstanding Technological Innovation and Entrepreneurship Program of Overseas Students, No. 3D510A941460; the Base Projects of Science and Technology Department of Jilin Province, No. 201215025

Abstract:

BACKGROUND: Based on the chemical composition and physical structure, graphene nanosheets can be used to form a very similar biological micro-environment to the extracellular matrix.

OBJECTIVE: To review the preparation, cytocompatibility and cell interaction of graphene-based three-dimensional scaffolds in recent years.

METHODS: A computer-based search of CNKI, ACS-ACS Publications, Elsevier Science, Nature and PNAS was performed to retrieve articles related to the type, preparation and application of biomedical graphene in tissue engineering.

RESULTS AND CONCLUSION: Graphene and its derivatives are made as a module, and based on its two-dimensional structural characteristics or functional groups enriched in oxidized graphene, graphene nanosheets can be assembled in different ways to build a three-dimensional macroscopic structure that is easy to compound other functional materials. Compared with a single graphene sheet or carbon nanomaterials, three-dimensional macroscopic graphene and its composite materials will be more likely to form new and unique structures and properties, which have more practical values and possess the functions of tissue engineering scaffolds.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Graphite, Tissue Engineering, Extracellular Matrix

CLC Number: