Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (34): 5473-5479.doi: 10.3969/j.issn.2095-4344.2015.34.013

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Biocompatibility of a new titanium alloy containing copper

Ren Bao-rui1, Liu Jie2, Zhang Er-lin3, Dong Hui4   

  1. 1Stomatological Hospital of Jiamusi University, Jiamusi 154007, Heilongjiang Province, China; 2Medical School of Qingdao University, Qingdao 266000, Shandong Province, China; 3Northeastern University, Shenyang 110819, Liaoning Province, China; 4Second Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Heilongjiang Province, China
  • Online:2015-08-20 Published:2015-08-20
  • Contact: Liu Jie, M.D., Professor, Medical School of Qingdao University, Qingdao 266000, Shandong Province, China
  • About author:Ren Bao-rui, Master, Stomatological Hospital of Jiamusi University, Jiamusi 154007, Heilongjiang Province, China
  • Supported by:

    the National Basic Research Program of China, No. 2012CB619100; the National Natural Science Foundation of China, No. 81071262/H1820; the Scientific Innovation Team Program in Universities of Heilongjiang Province, No. 2012TD010; the Natural Science Foundation of Heilongjiang Province, No. JC201205 

Abstract:

BACKGROUND: Copper-titanium alloy has been fabricated in previous studies to improve the antibacterial property and biocompatibility of titanium materials.

OBJECTIVE: With reference to the principle and experimental method specified by GB/T16886-ISO10993, to fully and systematically assess the biocompatibility of copper-titanium alloy.

METHODS: Based on the pre-experimental results, titanium alloy containing 10% copper was selected and subjected to oral mucosa stimulation experiment, skin stimulation test, acute systemic toxicity test, hemolytic test, prothrombin time test and dynamic coagulation test for biocompatibility evaluation.

RESULTS AND CONCLUSION: The copper-titanium alloy has no oral mucous membrane irritation, no short-term systemic toxicity, no skin sensitization, and no hemolysis, indicating it has a good biocompatibility.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Material Testing, Titanium, Biocompatible Materials

CLC Number: