Application of nano-artificial bone in anterior cervical fusion

doi:10.3969/j.issn.2095-4344.2015.34.012

Abstract

Abstract:

BACKGROUND: Nano-hydroxyapatite/polyamide artificial bone has good biocompatibility and strong tissue binding force, which exerts a significant role in the recovery of neurological function.

OBJECTIVE: To investigate the clinical effect of nano-hydroxyapatite/polyamide artificial bone in anterior cervical fusion.

METHODS: Ninety patients with cervical spondylosis and traumatic dislocation of the cervical spine were randomized into observation group and control group. Patients in the two groups underwent nano-hydroxyapatite/polyamide artificial bone and autologous iliac bone implantation, respectively. Surgical condition, Japanese Orthopaedic Association score, vertebral height loss and bone fusion rate were compared and analyzed at different time after implantation.

RESULTS AND CONCLUSION: There were no significant differences in surgical time, out of bed time, postoperative hospitalization time between the two groups (P > 0.05), but the intraoperative blood loss was significantly lower in the observation group than the control group (P < 0.05). Japanese Orthopaedic Association scores were significantly increased in the two groups at 3 and 6 months after operation and at last follow-up than before (P < 0.05), but there was no difference in the Japanese Orthopaedic Association score between the two groups (P > 0.05). The vertebral height loss and bone fusion rate had no difference between the two groups at 6 months after operation and at the last follow-up (P > 0.05). No adverse effects occurred in the two groups. These findings indicate that nano-hydroxyapatite/polyamide artificial bone has good clinical effects in anterior cervical fusion, and the treatment effect is equivalent to autologous iliac bone graft.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Spinal Fusion, Durapatite, Nylons

CLC Number:

R318

Liu Xing, Tian Li-jun, Deng Zhi-gang, Guo Yu-song. Application of nano-artificial bone in anterior cervical fusion[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(34): 5468-5472.

Figures/Tables 4

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