Biological characteristics of different sources of mesenchymal stem cells

doi:10.3969/j.issn.2095-4344.2015.32.029

Abstract

Abstract:

BACKGROUND: Mesenchymal stem cells, under in vivo or in vitro specific induction conditions, can differentiate into the cartilage, muscle, tendons and so on. Clinical trials concerning mesenchymal stem cells mainly include tissue repair (such as bone, cartilage and joint repair) and treatment of heart, liver, spinal cord injury and nervous system diseases.
OBJECTIVE: To compare the biological characteristics of mesenchymal stem cells from different sources.
METHODS: PubMed and CNKI databases were retrieved for articles related to sources of mesenchymal stem cells and biological characteristics of mesenchymal stem cells published from 1987 to 2015. The retrieved articles were summarized and analyzed in the following aspects: cell surface marker, proliferation, differentiation, migration, and function, so as to explore the merits and demerits of mesenchymal stem cells from different sources.
RESULTS AND CONCLUSION: A difference in the proliferation ability and surface markers is found between different sources of mesenchymal stem cells. Immunological competence of mesenchymal stem cells from different sources may be correlated with their activation status, species differences, tissue sources and culture conditions, resulting the immunological competence of mesenchymal stem cells from different sources is not exact the same. In-depth understanding of the factors and mechanisms by which influence the migration of mesenchymal stem cells from different sources can enhance the migration ability of different sources of mesenchymal stem cells, and increase their efficiency in wound healing, tissue repair and regeneration treatment.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Mesenchymal Stem Cells, Cell Proliferation, Cell Differentiation, Antigens, Surface

CLC Number:

R394.2

Fang Hong-song, Zhou Jian-lin, Peng Hao, Deng Shuang, Weng Jin-qing, Liu Feng, Chen Sen, Zhou Guan-jin. Biological characteristics of different sources of mesenchymal stem cells[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(32): 5243-5248.

Figures/Tables 1

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