Application of placental mesenchymal stem cells

doi:10.3969/j.issn.2095-4344.2015.32.028

Abstract

Abstract:

BACKGROUND: Placental mesenchymal stem cells are becoming a new source of seed cells because of wide range of sources, low immunogenicity and not involving ethical issues.
OBJECTIVE: To elaborate the sources, biological characteristics and latest application of placental mesenchymal stem cells.
METHODS: Literature search was performed in PubMed, ScienceDirect, OvidSP, CNKI databases for relevant literatures published from 2003 to 2015. The key words were “placenta, mesenchymal stem cells, placenta mesenchymal stem cells, cell transplantation, application mechanism” in Chinese and English, respectively. Then, 57 papers were further analyzed and reviewed in line with the theme.
RESULTS AND CONCLUSION: Placental mesenchymal stem cells have been isolated and cultured successfully, and confirmed to have multi-differentiation potential. A large number of placental mesenchymal stem cells have been used in the experimental animal and clinical researches, and they have a great potential in bone tissue engineering, revascularizaion and nerve repair. However, the specific mechanism underlying the application of placental mesenchymal stem cells is not clear. In order to ensure the safety and effectiveness, there are still many problems to be further studied before placental mesenchymal stem cells are widely used in clinic.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Placenta, Mesenchymal Stem Cells, Stem Cell Transplantation

CLC Number:

R318

Niu Ting, Li Ai-bin, Cao Jing-yun, Shen Lan, Chen Li. Application of placental mesenchymal stem cells[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(32): 5236-5242.

Figures/Tables 1

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