Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (29): 4731-4735.doi: 10.3969/j.issn.2095-4344.2015.29.027

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Procollagen type 1 N-terminal propeptide and beta-collagen special sequence for the diagnosis and treatment of osteoporosis

Zou Jun1, Yuan Chen-xi1, Zhu Hong-jun2, Lu Ying2, Lin Min2, Chen Yi-jia2, Wang Jun-hua1, Xu Jia-xuan1   

  1. 1Department of Orthopedics, First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China; 
    2Health Center of Shuangta Subdistrict Community, Suzhou 215006, Jiangsu Province, China
  • About author:Zou Jun, Master, Attending physician, Department of Orthopedics, First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81101370, 81472132; Clinical Science and Technology Projects in Jiangsu Province, No. BL2012004; the Priority Academic Program Development of Jiangsu Higher Education Institutions; the Natural Science Foundation of Jiangsu Higher Education, No. 12KJB320008; the Graduate Scientific Research Innovation Project of Jiangsu Higher Education, No. CXZZ11_0126; Suzhou Technology Support Program for Social Development, No. SS201331

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Abstract:

BACKGROUND: Procollagen type 1 N-terminal propeptide (P1NP) and β-collagen special sequence (β-CrossLaps) are two bone metabolic markers that are closely related to osteoporosis. Combined detection of bone metabolic markers and bone mineral density is of clinical significance for the diagnosis of osteoporosis. Bone metabolic markers are ideal indicators to predict fractures, which can compensate for the lack of bone density test.

OBJECTIVE: To introduce the application of bone metabolic markers in the monitoring of drug efficacy on the treatment of osteoporosis as well as in the prediction of fracture risks in recent 20 years and to explore the clinical values of P1NP and β-CrossLaps to assess the therapeutic efficacy on osteoporosis and risks for osteoporotic fractures.
METHODS: A computer-based search of CNKI and SCI databases were performed for relevant articles published from 2000 to 2014 using the keywords of “serum bone metabolic markers; osteoporosis; bone mineral density” in Chinese and English, respectively. Finally, 44 articles meeting the inclusive criteria were reviewed.
RESULTS AND CONCLUSION: This paper analyzes the source and detection mechanisms of P1NP and β-CrossLaps and then compares their advantages in the therapeutic effect assessment of osteoporosis. Serum bone metabolic markers cannot only reflect the dynamic changes of bone metabolism, but also have earlier changes than the bone mineral density. Both P1NP and β-CrossLaps are very important for assessing the early diagnosis of osteoporosis as well as anti-osteoporosis drug efficacy.

 中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Osteoporosis, Bone Density, Collagen

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