The protective effect of TanshinoneⅡA on rat models of uterine ischemia/reperfusion injury

doi:10.3969/j.issn.2095-4344.2015.27.022

Abstract

Abstract:

BACKGROUND: The phenomenon of temporary ischemia of the tissues and organs caused by injury is common in the clinic. However, there are few studies on the treatment of ischemia/reperfusion injury. It is significant to investigate the effect of TanshinoneⅡA on improving uterine ischemia/reperfusion injury in a rat model.
OBJECTIVE: To observe the effect of TanshinoneⅡA intervention on improving uterine ischemia/reperfusion injury in rats.
METHODS: The rat models of uterine ischemia/reperfusion injury were established by suture method. The rats that were intraperitoneally injected with Sodium Tanshinone IIA Silate injection (20 mg/kg) at 5, 3, 1 days and 30 minutes before the operation were included in the experimental group. Model and sham operation groups were established for comparison.
RESULTS AND CONCLUSION: Spectrophotometry and immunohistochemical staining results showed that at 1 and 3 hours of ischemia/reperfusion, the malondialdehyde concentration and Bax protein expression in the injuried rat uterine tissue were significantly decreased (P < 0.05), superoxide dismutase (SOD) activity and Bcl-2 protein expression were significantly increased (P < 0.05) in the experimental group than in the model group. The results confirm that TanshinoneⅡA has a protective effect on uterine ischemia/reperfusion injury in rats.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

Key words: Tissue Engineering, Animal Model, Uterus

CLC Number:

R318

Wang Dong, Ji Xiao-wei, Zhang Shuang. The protective effect of TanshinoneⅡA on rat models of uterine ischemia/reperfusion injury [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(27): 4384-4388.

Figures/Tables 3

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