Insulin-like factor, testosterone and bone metabolism indexes in the prediction of osteoporotic fractures in elderly men

doi:10.3969/j.issn.2095-4344.2015.24.002

Abstract

Abstract:

BACKGROUND: The domestic incidence of osteoporosis in elderly men has an increasing trend with aging. Osteoporosis patients are prone to fracture, which can pose a serious threat to patient’s life and safty, but there is still a lack of effective screening measures to prevent its occurrence.
OBJECTIVE: To explore the clinical significance of insulin-like factor, testosterone and bone metabolism index levels in the prediction of osteoporotic fracture in elderly men. METHODS: Totally 120 male patients with osteoporotic fractures were enrolled as observation group, and another 120 healthy males with no osteoporosis admitted at the same period acted as controls. There were no differences in age and body mass index between the two groups. Insulin-like factor, testosterone and bone metabolism index levels were detected and compared between the two groups.
RESULTS AND CONCLUSION: Compared with the control group, the bone mineral densities of the lumbar vertebrae and left femoral neck were significantly lower in the observation group (P < 0.05), and the levels of insulin-like factor and serum testosterone were also significantly lower in the observation group (P < 0.05), but the levels of collagen type I C-terminal foreign bodies and β-CTX were significantly higher in the observation group. No significance was found in the osteocalcin, serum calcium, serum phosphorus levels between the two groups (P > 0.05). These findings suggest that the serum testosterone, insulin-like factor and some bone metabolism indexes can be used for prediction of osteoporotic fractures in elderly men, which have a certain reference value.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Bone Density, Testosterone, Osteoporosis

CLC Number:

R318

Liu Xuan-min . Insulin-like factor, testosterone and bone metabolism indexes in the prediction of osteoporotic fractures in elderly men [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(24): 3778-3782.

Figures/Tables 4

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