Abstract:

BACKGROUND: Biomaterial combined with stem cells is revealing a bright future in bone tissue regeneration in orthopedic surgery. Induced pluripotent stem cells have better cell sources and characteristic, which have become a hotspot of stem cell field.
OBJECTIVE: To review the research history, preparation method, cell characteristics of induced pluripotent stem cells and the research developments in orthopeadic surgery so far.
METHODS: A computer-based search of CNKI and PubMed was performed for articles about induced pluripotent stem cells and their applications in the field of orthopeadic surgery published from 1999 to 2014. Typical and creative research achievements were enrolled in result analysis.
RESULTS AND CONCLUSION: Studies have shown that induced pluripotent stem cells have a potential application prospect in bone tissue regeneration, and they also show a satisfying biocompatibility with various scaffold materials, in which, the induced pluripotent stem cells can maintain a good osteogenetic potential. Detection methods and small-molecule compounds have been discovered gradually for cartilage regeneration. But how to effectively induce the chondrogenic differentiation of induced pluripotent stem cells and to realize the clinical applications need further research.


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words:  Multipotent Stem Cells, Induced Pluripotent Stem Cells, Bone and Bones, Regeneration