Hyaluronic acid for the treatment of chronic periodontitis can effectively promote periodontal tissue regeneration

doi:10.3969/j.issn.2095-4344.2014.47.019

Abstract

Abstract:

BACKGROUND: Hyaluronic acid has antioxidant, immune regulation, anti-inflammatory roles as well as promotes wound healing. Hyaluronic acid is more and more applied in the treatment of chronic periodontitis and achieves a significant effect.
OBJECTIVE: To observe the clinical effects of local application of sodium hyaluronate in the treatment of chronic periodontitis.
METHODS: Sixty cases of chronic periodontitis (300 teeth) were selected. According to self-control method, the teeth in district A, 150 premolars or molars, were as experimental group, and other 150 teeth in district B served as control group. In the experimental group, periodontal scaling, subgingival scaling, and local application of Gengigel gel (0.2% hyaluronic acid) in the gingival sulcus were employed; in the control group, the treatment was same to that in the experimental group except local application of Gengigel gel. During 8-week follow-up, dental plaque index, sulcus bleeding index, probing depth, and clinical attachment loss were changed dynamically.
RESULTS AND CONCLUSION: After treatment, all the measurement indexes were improved remarkably in the two groups. However, there was no difference in the dental plaque index between the two groups at 1, 4, 8 weeks after treatment. The sulcus bleeding index was lower in the experimental group than the control group at 1, 4, 8 weeks after treatment (P < 0.05). The periodontal probing depth of the experimental group was lower than that of the control group at 4 and 8 weeks (P < 0.05). The clinical attachment loss was lower in the experimental group than the control group at 8 weeks (P < 0.05). These findings indicate that periodontal treatment with local application of sodium hyaluronate in the gingival sulcus is significantly effective for the treatment of chronic periodontitis.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: hyaluronic acid, chronic periodontitis, dental plaque index

CLC Number:

R318

Yao Xi, Li Yun-sheng, Li Hong-mei, Dai Yong-yu. Hyaluronic acid for the treatment of chronic periodontitis can effectively promote periodontal tissue regeneration[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(47): 7648-7652.

Figures/Tables 1

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