Chinese Journal of Tissue Engineering Research ›› 2014, Vol. 18 ›› Issue (30): 4868-4872.doi: 10.3969/j.issn.2095-4344.2014.30.018

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Ultrasonic controlling of degradation of polymer materials

Gao Xi-xiang1, Zhang Jian1, Chen Bing1, Gu Yong-quan1, Li Jian-xin1, Zhang Shu-wen1, Ye Lin2, Feng Zeng-guo2   

  1. 1Institute of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
    2School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, China
  • Revised:2014-05-24 Online:2014-07-16 Published:2014-08-08
  • Contact: Zhang Jian, Chief physician, Professor, Institute of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • About author:Gao Xi-xiang, M.D., Xuanwu Hospital, Capital Medical University, Beijing 100053, China
  • Supported by:

    the National Natural Science Foundation of China, No. 30972944; Capital Medicine Clinical Application Project by Beijing Municipal Science andTechnology Commission, No. Z131107002213041

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Abstract:

BACKGROUND: Degradable polymer materials initiate the degradation process immediately after implantation. How to regulate the degradation of these materials is rarely reported at present.
OBJECTIVE: To study the effect of ultrasonic wave on controlling the degradation of polymer materials.
METHODS: The sample is made of ε-caprolactone/L-lactide copolymer, and its core was coated with low density polyethylene on the surface with the following four different methods. (1) The core surface was firstly covered with CaCl2 powder, and then coated with polyethylene. (2) The core was firstly coated with polyethylene and coarsened for 3 hours. (3) The core surface was firstly covered with CaCl2 powder, and then coated with polyethylene, and coarsened for 3 hours. (4) The core was directly coated with polyethylene. The four kinds of specimens obtained were embedded in pork for ultrasonic bombardment experiment in vitro.
RESULTS AND CONCLUSION: In the specimens prepared with methods 1 and 4, the lyophobic layer could protect core materials before ultrasonic treatment, and no absorption peak was found at 631 nm. After ultrasonic treatment, the lyophobic layer was destroyed, toluidine blue dye was released, leading to change the color of immersion solution and increase the absorption peak at 631 nm. In the specimens prepared with methods 2 and 3, the lyophobic layer cannot exhibit the protection effects, the absorption peak was found at 631 nm. Under electron microscope, the appearance of the specimens in four groups was changed obviously. It is feasible to control the starting of the degradation by coating the degradable copolymer with LDPE and using ultrasonic as a trigger.


中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程


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Key words: polyethylene, biodegradation, environmental, polymers

CLC Number: