Umbilical cord mesenchymal stem cell transplantation for the treatment of diabetes mellitus in rats

doi:10.3969/j.issn.2095-4344.2014.19.023

Abstract

Abstract:

BACKGROUND: Umbilical cord mesenchymal stem cells have strong proliferation and differentiation capacities, and can be induced to differentiate into pancreatic β cells, thereby playing a therapeutic effect on diabetes mellitus.
OBJECTIVE: To study the therapeutic effects of transplantation of umbilical cord mesenchymal stem cells for treatment of diabetes mellitus in rats.
METHODS: Thirty male Sprague-Dawley rats were randomly divided into control group (n=6), transplantation group (n=12) and diabetic group (n=12). Rats in the control group were given normal saline injection. Rats in the other two groups were injected with streptozotocin at a dose of 45 mg/kg to establish diabetic models. After modeling, transplantation of umbilical cord mesenchymal stem cells via tail vein was given in the transplantation group.
RESULTS AND CONCLUSION: Thirty days after modeling, the fasting blood glucose was maintained at a higher level in comparison with the control group (P < 0.05). However, compared with the diabetic group, the level of fasting blood glucose was significantly reduced (P < 0.05) and the body mass was increased in the transplantation group (P < 0.05). After 45 days, the fasting blood glucose level and body mass in the transplantation group had no significant difference from those in the control group (P > 0.05), but in the diabetic group, the fasting blood glucose level was still higher and the body mass continued to decrease. These findings indicate that the transplantation of umbilical cord mesenchymal stem cells can be effective in the treatment of diabetes mellitus in rats.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words: umbilical cord, cord blood stem cell transplantation, diabetes mellitus, diabetes mellitus, experimental, blood glucose

CLC Number:

R394.2

Li Li, Zhao Bo. Umbilical cord mesenchymal stem cell transplantation for the treatment of diabetes mellitus in rats[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(19): 3094-3099.

Figures/Tables 3

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