Efficacy and safety of transverse tibial bone transport technique in the treatment of diabetic foot:a meta-analysis#br#

doi:10.3969/j.issn.2095-4344.3200

Abstract

Abstract: OBJECTIVE: Transverse tibial bone transport technique is an emerging treatment for diabetic foot in recent years. At present, a large number of studies have confirmed its significant efficacy and high safety in the treatment of diabetic foot, but there is still a lack of evidence. Therefore, a meta-analysis on the treatment of diabetic foot by transverse tibial bone transport technique was conducted.
METHODS: CNKI, VIP, WanFang, PubMed, Cochrane library, and EMbase were searched for randomized controlled trials regarding transverse tibial bone transport technique for the treatment of diabetic foot. The retrieval time was from inception to February 2020. The quality of the included literature was strictly evaluated, and the Rev Man5.3 software was used for the meta-analysis of amputation rate, healing rate, healing time, skin temperature and Visual Analogue Scale pain score.
RESULTS: A total of 8 randomized controlled trials involving 837 cases were included, with 428 cases in treatment group and 409 in control group. The literature quality evaluation results showed that: the quality evaluation of the case-control experiment was carried out according to the Newcastle-Ottawa Scale, with 2 papers scoring 7 points; according to the improved Jadad scale, four randomized controlled trials were evaluated with 4 marks and two evaluated with 2 marks. Meta-analysis results showed that compared with the control group, the amputation rate [odds ratio (OR)=0.12, 95% confidence interval (CI) (0.05, 0.26), P < 0.000 01), healing rate [OR=28.65, 95%CI (16.45, 49.88), P < 0.000 01), healing time (OR=2.61, 95%CI (-4.23, -0.98), P=0.002], skin temperature (OR=2.44, 95%CI (2.27, 2.61), P < 0.000 01), Visual Analogue Scale score (standard mean difference=-6.41, 95%CI (-9.50, -3.32), P < 0.000 1) were all improved in the treatment group with transverse tibial bone transport for treating diabetic foot .
CONCLUSION: Transverse tibial bone transport technique is of high safety and has significant advantages over conventional treatments in the treatment of diabetic foot. Limited by the quantity and quality of included studies, the above conclusions need to be verified by more high-quality studies.

Key words: bone, tibia, bone transport, diabetes mellitus, ulcer, healing, amputation, meta-analysis

CLC Number:

Tian Lin, Shi Xiaoqing, Duan Zhenglan, Wang Kuan, Zhang Li, Wang Peimin. Efficacy and safety of transverse tibial bone transport technique in the treatment of diabetic foot:a meta-analysis#br#[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(20): 3275-3280.

Figures/Tables 8

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