Rapid prototyped titanium plate combined with autologous cancellous bone graft repairs canine mandibular defects

doi:10.3969/j.issn.2095-4344.2014.15.018

Abstract

Abstract:

BACKGROUND: Rapid prototyping technique has been recently applied in the medical reconstruction and allows the production of individual implant for patients with tissue defects, achieving an accurate repair.
OBJECTIVE: To repair discontinuous mandibular defects in dogs using rapid prototyped titanium plate in combination with autologous cancellous bone graft.
METHODS: Nine hybrid canines were used, and the skull was scanned using spiral CT. Then CT data were used to construct three-dimensional digital model, in which virtual partial mandibulectomy was performed, and an individualized bone-grafting plate was designed. A titanium plate was manufactured using rapid prototyping and titanium casting. Animal experiment was then performed. A 40-mm discontinuous defect in the right mandibular body was created in the involved dogs. The defect was restored immediately using the customized plate in combination with autologous cancellous iliac blocks. Sequential radionuclide bone imaging, biomechanical testing, three-dimensional microcomputed tomographic scanning, radiology and histological examination were used to evaluate the turnover of the grafts.
RESULTS AND CONCLUSION: A symmetric mandible was reconstructed using the rapid prototyped grafting plate. The grafted bone survived and got corticalized, while a fibrous intermedium was found between the bone graft and the plate. In the reconstruction of mandibular defects, optimal functional and aesthetic outcomes could be achieved using the rapid prototyped grafting plates.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: mandible, titanium, braces, ilium, bone transplantation, tomography, spiral computed

CLC Number:

R318

Zhou Li-bin, Wu Wei, Wang Pei-lin, Ding Rui-ying, Han Hao-lun, Li Bao-wei, Wang Gang, Wang Hong-nan, Zhao Jin-long, Liu Yan-pu . Rapid prototyped titanium plate combined with autologous cancellous bone graft repairs canine mandibular defects[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(15): 2403-2408.

Figures/Tables 8

References

[1]Zhou L, Shang H, He L, et al. Accurate Reconstruction of Discontinuous Mandible Using a Reverse Engineering/ Computer-Aided Design/Rapid Prototyping Technique: A Preliminary Clinical Study. J Oral Maxillofac Surg. 2010;68(9): 2115-2121.
[2]Zhou L, Zhao J, Shang H, et al. Reconstruction of Mandibular Defects Using a Custom-Made Titanium Tray in Combination with Autologous Cancellous Bone. J Oral Maxillofac Surg. 2011;69(5):1508-1518.
[3]Torres K, Sta?kiewicz G, ?nie?yński M, et al. Application of rapid prototyping techniques for modelling of anatomical structures in medical training and education. Folia Morphol (Warsz). 2011;70(1):1-4.
[4]Bagaria V, Deshpande S, Rasalkar DD, et al. Use of rapid prototyping and three-dimensional reconstruction modeling in the management of complex fractures. Eur J Radiol. 2011; 80(3):814-820.
[5]Kim MS, Hansgen AR, Carroll JD. Use of rapid prototyping in the care of patients with structural heart disease. Trends Cardiovasc Med. 2008;18(6):210-216.
[6]El-Ghannam A, Hart A, White D, et al. Mechanical properties and cytotoxicity of a resorbable bioactive implant prepared by rapid prototyping technique. J Biomed Mater Res A. 2013; 101(10):2851-2861.
[7]Cho SH, Chang WG. Mirror-image anterior crown fabrication with computer-aided design and rapid prototyping technology: a clinical report. J Prosthet Dent. 2013;109(2):75-78.
[8]龚振宇,刘彦普,周树夏,等. 基于反求工程和快速原型的下颌骨缺损的修复[J].中华口腔医学杂志,2004,39(1):9-11.
[9]赵晋龙,刘彦普,商洪涛,等. 应用反求与快速原型技术修复下颌骨缺损[J]. 实用口腔医学杂志,2009,25(2):214-217.
[10]龚振宇,李国华,许瑞杰,等. 下颌骨缺损个体化修复体的应力分析与优化设计[J]. 中国组织工程研究与临床康复,2011, 15(39): 7242-7246.
[11]周丽斌,刘彦普,胡曼,等. 利用核医学方法检测自体移植骨在个体化支架内的转归[J]. 实用口腔医学杂志,2008,24(4): 465-569.
[12]周丽斌,程久兵,张胜良,等. 个体化钛重建板结合自体骨移植修复犬下颌骨缺损[J].实用口腔医学杂志,2013,29(4):36-40.
[13]罗耀武,唐安戊,乔穗宪,等. 99Tcm-MDP 骨显像判断下颌骨植骨成活的价值[J]. 中华核医学杂志,1999,19(2):103.
[14]黄若昆,谢鸣,方真华,等. 99 Tcm-MDP骨显像监测可注射组织工程骨的成骨活性[J].中国组织工程研究与临床康复,2010,14(25): 4573-4576.
[15]蔡良,曾贵刚,乔伟伟,等. SPECT/CT骨显像诊断兔应力性骨折的实验研究[J]. 实验动物与比较医学,2013,33(4):265-270.
[16]白永利,迟达超,阎立昆. 放射性计数半定量法用于观察骨质代谢异常探讨[J]. 现代肿瘤医学,2013,21(7):1610-1612.
[17]杨淑贞,刘英,朱传明,等. SPECT/CT同机图像融合在核素骨显像中的应用[J]. 中国现代医药杂志,2013,15(4):100-102.
[18]Parsa A, Ibrahim N, Hassan B, et al. Bone quality evaluation at dental implant site using multislice CT, micro-CT, and cone beam CT. Clin Oral Implants Res. 2013.
[19]Yang S, Hollister AM, Orchard EA, et al. Quantification of bone changes in a collagen-induced arthritis mouse model by reconstructed three dimensional micro-CT. Biol Proced Online. 2013;15(1):8.
[20]张钧,江莉婷,王晋申,等. 1型糖尿病小鼠下颌骨三维结构及组织形态[J]. 中国组织工程研究,2013,17(28):5101-5107.