Open autologous minimal morselized bone grafting with vancomycin repairs infected tibial defects

doi:10.3969/j.issn.2095-4344.2013.25.004

Abstract

Abstract:

BACKGROUND: Studies have shown that 300-500 μm minimal morselized bone is easier than 4.0-5.0 mm morselized bone to survive in non-infected bone defects.
OBJECTIVE: To investigate and evaluate the feasibility and clinical effect of open autologous minimal morselized bone grafting with vancomycin to treat infected tibial defects.
METHODS: Twenty-eight patients with infected tibial defects or nonunion were treated with open autologous minimal morselized bone grafting, including 23 males and five females, aged from 9 to 58 years (average age of 35.2 years). There were 19 cases of upper tibial defects, two cases of middle tibial defects, and seven cases of distal tibial defects. After open fracture operation, there were 17 cases of postoperative infections and 11 cases of postoperative infection and bone nonunion. All the patients were followed up for 6-30 months for wound and fracture healing.
RESULTS AND CONCLUSION: Transplanted minimal morselized bone was covered with granulation tissue after postoperative 6 weeks, and wound was completely closed after postoperative 8 weeks. Two cases of poor facture healing achieved bone healing after secondary bone graft. The mean healing duration was 5 months. No neurovascular injury and drug susceptibility reaction occurred. These findings indicate that open autologous minimal morselized bone grafting with vancomycin is feasible to treat infected tibial defects.

Key words: biomaterials, tissue-engineered bone materials, autologous minimal morselized bone, bone grafting, infections, bone defects, bone nonunion, antibiotics, provincial grants-supported paper

CLC Number:

R318

Nan Chong, Jing Hao, Zhou Yue, Qiu Shao-dong, Bo Yu, Hu Ning-min. Open autologous minimal morselized bone grafting with vancomycin repairs infected tibial defects [J]. Chinese Journal of Tissue Engineering Research, 2013, 17(25): 4585-4592.

Figures/Tables 4

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