Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (16): 2618-2624.doi: 10.3969/j.issn.2095-4344.3171
Tian Lin, Shi Xiaoqing, Mao Jun, Zhang Nongshan, Zhang Li, Xing Runlin, Wang Peimin
Received:
2020-05-20
Revised:
2020-05-21
Accepted:
2020-06-12
Online:
2021-06-08
Published:
2021-01-07
Contact:
Wang Peimin, Chief TCM physician, MD, Doctoral supervisor, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
About author:
Tian Lin, Master candidate, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Supported by:
CLC Number:
Tian Lin, Shi Xiaoqing, Mao Jun, Zhang Nongshan, Zhang Li, Xing Runlin, Wang Peimin. Meta-analysis of vacuum-sealing drainage combined with antibiotic bone cement in the treatment of chronic osteomyelitis[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(16): 2618-2624.
根据样本量大小的不同进行亚组分析,结果显示在样本量<50(P=0.55,I2=0;MD=-17.39,95%CI:-19.00至-15.78,P < 0.000 01)和样本量≥50(P=0.45,I2=0,MD=-2.08,95%CI:-3.94至-0.22,P=0.03)的亚组中,异质性均显著降低,负压封闭引流联合抗生素骨水泥治疗慢性骨髓炎在创面愈合时间方面均短于对照组。 2.3.4 各组抗生素使用时间变化 共3篇文献报道了抗生素使用时间[12-13,18],结果显示数据异质性较低(P=0.18,I2=43%),故采用固定效应模型计算合并效应量,结果显示负压封闭引流联合抗生素骨水泥治疗慢性骨髓炎在抗生素使用时间方面低于对照组(MD=-12.36,95%CI:-13.27至-11.44,P < 0.000 01),见图7。 "
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