Autologous bone marrow cell transplantation combined with hyperbaric oxygen for the treatment of bone nonunion of four limbs

doi:10.3969/j.issn.2095-4344.2013.19.015

Abstract

Abstract:

BACKGROUND: Bone nonunion due to a variety of causes after fracture is a common orthopedic complication. The existing operation therapy cannot be satisfied with the efficacy. Looking for a minimally invasive, safe and effective treatment method has become the research focus of the orthopedic scholars.
OBJECTIVE: To observe the clinical curative effect of autologous bone marrow cell transplantation combined with hyperbaric oxygen in the treatment of nonunion of four limbs.
METHODS: Under routine disinfection and local anesthesia, 10-20 mL bone marrow was extracted from patients to separate, condense and prepare bone marrow cell suspension 2-4 mL. The autologous bone marrow cell concentrate was injected to the nonunion site at the multi-punctures under the guidance of positioning of the C-arm X machine. Sterile dressings were performed after local compression for 3-5 minutes. Hyperbaric oxygen therapy was performed after engraftment of bone marrow cells immediately, 10 times as one course. There was an interval of 5 days between the two courses, a total of three courses.
RESULTS AND CONCLUSION: Of 37 nonunion cases, 36 cases were healed, and the efficacy assessment was excellent in 25 cases, good in eight cases, general in three cases, and poor in one case; the average time of callus formation was (7.22±1.96) weeks, and the average healing time was (7.91±1.79) months. After bone marrow cell implantation, no serious complications occurred. Autologous bone marrow cell transplantation combined with hyperbaric oxygen for the treatment of bone nonunion can promote the healing of nonunion, which is an effective treatment method.

Key words: stem cells, stem cell transplantation, clinical application of stem cells, nonunion, bone marrow cells, fractures, hyperbaric oxygen, percutaneous puncture, injection, digital subtraction angiography, interventional radiology, treatment

CLC Number:

R394.2

Zhang Chuan-kai, Shi Yue, Sun Yang, Feng Hui, Liu Ying, Han Bing, Liu Jun-quan. Autologous bone marrow cell transplantation combined with hyperbaric oxygen for the treatment of bone nonunion of four limbs[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(19): 3515-3520.

Figures/Tables 2

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