Association of bone mineral density with left ventricular mass index in the elderly women

doi:10.3969/j.issn.2095-4344.2013.11.005

Abstract

Abstract:

BACKGROUND: There is an association between cardiovascular disease and osteoporosis in elderly women. Left ventricular hypertrophy is the independent determining factor for cardiovascular events. Osteoporosis and left ventricular hypertrophy might be linked by some common pathological mechanisms.
OBJECTIVE: To investigate the association between bone mineral density and left ventricular mass index in the elderly women.
METHODS: Totally 157 elderly women were enrolled and divided into a normal group, bone loss group and osteoporosis group according to the bone mineral density. Bone mineral density, echocardiography measurements as well as the measurements of blood biochemical markers were analyzed. Left ventricular mass index was obtained by echocardiography. One-way analysis of variation and multiple stepwise linear regression analyses were performed for identifying determinants of left ventricular mass index.
RESULTS AND CONCLUSION: With the increasing of bone loss, left ventricular mass index and prevalence of left ventricular hypertrophy were increased significantly (P < 0.05). Multiple stepwise linear regression analyses demonstrated that the lumbar and femoral bone mineral density was correlated with left ventricular mass index, and the association remained statistically significant after adjusting for age, systolic blood pressure, fasting blood glucose, serum creatinine and blood lipid. Age, systolic blood pressure, and lumbar or femoral bone mineral density were independent predictors of left ventricular mass index. In the elderly women, bone mineral density may be an independent determining factor for left ventricular mass index.

Key words: tissue construction, bone tissue construction, bone mineral density, bone mass, osteoporosis, left ventricular hypertrophy, left ventricular mass index, echocardiography, hypertension, coronary heart disease, cardiovascular, elderly women

CLC Number:

R318

Wei Ya-nan, Chen Ling-xia, Miao Yi-de, Liu Jie, Jia Rong. Association of bone mineral density with left ventricular mass index in the elderly women[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(11): 1931-1938.

Figures/Tables 3

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