Intestinal absorption characteristics of curcumin hydroxypropyl-beta-cyclodextrin in rats: an analysis using one-way perfusion method

doi:10.3969/j.issn.2095-4344.1539

Abstract

Abstract:

BACKGROUND: Curcumin has good anticancer and anti-inflammatory effects, but which is limited for the low solubility.

OBJECTIVE: To investigate the intestinal absorption characteristics of curcumin hydroxypropyl-β-cyclodextrin and curcumin in rats.

METHODS: The curcumin hydroxypropyl-β-cyclodextrin was prepared by grinding method, and the solubility of curcumin hydroxypropyl-β-cyclodextrin and curcumin was detected. Twelve male Sprague-Dawley rats were used to establish a one-way perfusion model of intestinal segment (duodenum, jejunum, ileum and colon), and randomly divided into two groups. The experimental group was given curcumin hydroxypropyl-β-cyclodextrin, and the control group was perfused with curcumin suspension. The absorption rate (K_a) and effective permeability (P_app) of curcumin hydroxypropyl-β-cyclodextrin and curcumin at each intestinal segment were measured by ultraviolet-visible spectrophotometry.

RESULTS AND CONCLUSION: The solubility of curcumin hydroxypropyl-β-cyclodextrin in water was increased by 33.68 times compared with that of curcumin. The absorption rate constant (K_a) of curcumin hydroxypropyl-β-cyclodextrin was ranked as follows: duodenum > ileum > jejunum > colon, and the effective permeability (P_app) was ranked as follows: colon > duodenum > ileum > jejunum, and the absorption in the intestines was significantly higher than that of curcumin (P < 0.05). In summary, curcumin hydroxypropyl-β-cyclodextrin can obviously improve the absorption of curcumin in the intestines of rats.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Curcumin, beta-Cyclodextrins, Intestinal Absorption, Tissue Engineering

CLC Number:

Luo Jianchun, Guo Qi, Zhang Min, Zhong Meng, Wan Shengli, Zhang Jingqing. Intestinal absorption characteristics of curcumin hydroxypropyl-beta-cyclodextrin in rats: an analysis using one-way perfusion method[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(6): 957-962.

Figures/Tables 4

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