Sandwiched Moxibustion plus Bushen Quhan recipe for treating knee osteoarthritis: a randomized controlled trial

doi:10.3969/j.issn.2095-4344.1333

Abstract

Abstract:

BACKGROUND: Conservative treatment is a method for the early- and medium-term knee osteoarthritis. The concept of quality of life of patients has attracted much attention in the field of medicine.
OBJECTIVE: To observe the clinical effect and quality of life in Sandwiched Moxibustion plus Bushen Quhan recipe for treating knee osteoarthritis.
METHODS: One hundred patients of knee osteoarthritis were randomly divided into treatment group (n=50) and control group (n=50). The treatment group was given the Sandwiched Moxibustion plus Bushen Quhan recipe, and the control group was treated with loxoprofen sodium dispersible tablets and diacerein capsules. After 12 weeks of treatment, the Visual Analogue Scale score, Western Ontario and McMaster Universities Osteoarthritis Index and 36-Item Short Form Health Survey questionnaire were analyzed before and after treatment. The changes of total clinical efficacy and adverse reactions were observed. The study was approved by the Ethics Committee of Southern Medical University Affiliated Shilong People’s Hospital of Dongguan on May 11, 2017, approval number: 20170511.
RESULTS and CONCLUSION: After 12 weeks of treatment: (1) The Visual Analogue Scale scores in the treatment group was decreased significantly compared with the control group (P < 0.05). (2) The joint pain, joint stiffness and total cores of Western Ontario and McMaster Universities Osteoarthritis Index in the treatment group were significantly lower than those in the control group (P < 0.05). The scores of 36-Item Short Form Health Survey questionnaire in the treatment group were significantly higher than those in the control group (P < 0.05). (3) There was no significant difference in the total effectiveness or adverse reaction between two groups (P > 0.05). (4) These results suggest that the Sandwiched Moxibustion plus Bushen Quhan recipe has the similar clinical efficacy with oral loxoprofen sodium dispersible tablets and diacerein capsules for treating knee osteoarthritis. The former possesses more obvious effects in reducing joint pain, joint stiffness and total cores of Western Ontario and McMaster Universities Osteoarthritis Index and significantly improves the quality of life of patients.

Key words: tissue construction, bone tissue engineering, knee osteoarthritis, Sandwiched Moxibustion, Bushen Huoxue recipe, clinical efficacy, quality of life, randomized controlled trial

CLC Number:

Zhong Qiusheng, Xia Weichao, Guo Meizhen, Zhu Haiqing, Zhong Cuiqiong, Shao Jieqi, He Xiaohong, Chen Xiumin. Sandwiched Moxibustion plus Bushen Quhan recipe for treating knee osteoarthritis: a randomized controlled trial [J]. Chinese Journal of Tissue Engineering Research, 2019, 23(35): 5670-5675.

Figures/Tables 3

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