Low-intensity focused ultrasound and low-intensity pulsed ultrasound for mild traumatic knee osteoarthritis: differences in pain and function

doi:10.12307/2021.105

Abstract

Abstract:

BACKGROUND: Current studies have shown that both focused and pulsed ultrasound can effectively improve the pathological performance of traumatic knee osteoarthritis, but it is not clear whether there is a difference between the two therapies.

OBJECTIVE: To compare low-intensity focused ultrasound and low-intensity pulsed ultrasound in the treatment of mild traumatic knee osteoarthritis.
METHODS: A retrospective study was conducted in 60 mild traumatic knee osteoarthritis patients treated with low-intensity focused ultrasound (n=30) or low-intensity pulsed ultrasound (n=30). Patients in both groups received drug treatments combined with low-intensity pulsed ultrasound or low-intensity focused ultrasound for 8 weeks. Assessments and measurements were conducted before treatment, on the day after treatment, and 3 months after treatment, including Visual Analogue Scale for assessing pain, the Western Ontario and McMaster University (WOMAC) Osteoarthritis Index for assessing joint function of the affected knee, and ELISA kits for detecting serum levels of interleukin-1β, interleukin-6 and tumor necrosis factor α.
RESULTS AND CONCLUSION: Compared with pre-treatment data, the Visual Analog Scale score, WOMAC score, and serum inflammatory factor levels were significantly decreased after treatment with low-intensity focused ultrasound and low-intensity pulsed ultrasound (P < 0.05). This therapeutic effect lasted for at least 3 months. Low-intensity focused ultrasound induced lower Visual Analogue Scale score, WOMAC score, and serum levels of interleukin-6 and tumor necrosis factor α as compared to the low-intensity focused ultrasound. It is suggested that both low-intensity focused ultrasound and low-intensity pulsed ultrasound can effectively treat mild traumatic knee osteoarthritis, and the low-intensity focused ultrasound has a better outcome than the low-intensity pulsed ultrasound.

Key words: knee osteoarthritis, focused ultrasound, pulsed ultrasound, ultrasound intensity, pain, inflammatory factors, joint function

CLC Number:

Yue Heng, Zhen Ping, Liang Xiaodi. Low-intensity focused ultrasound and low-intensity pulsed ultrasound for mild traumatic knee osteoarthritis: differences in pain and function[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(26): 4101-4105.

Figures/Tables 5

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